SCOPe 2.06: Domain d2qmda_: 2qmd A:

Lineage for d2qmda_ (2qmd A:)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein beta-secretase (memapsin) [50671] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50672] (281 PDB entries)
   Uniprot P56817 58-446 ! Uniprot P56817 60-447

8. Domain d2qmda_: 2qmd A: [150878]
   automated match to d1fkna_
   complexed with cs7, tar

Details for d2qmda_

PDB Entry: 2qmd, 1.65 Å

PDB Description: structure of bace bound to sch722924

PDB Compounds: (A:) Beta-secretase 1

SCOPe Domain Sequences for d2qmda_:

Sequence; same for both SEQRES and ATOM records:

>d2qmda_ b.50.1.2 (A:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
gsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrql
sstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwe
gilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmii
ggidhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrl
pkkvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsf
ritilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfav
sachvhdefrtaavegpfvtldmedcgyni

Timeline for d2qmda_:

• d2qmda_ first appeared in SCOP 1.75, called d2qmda1
  
• d2qmda_ appears in SCOPe 2.05
  
• d2qmda_ appears in SCOPe 2.07
  
• d2qmda_ appears in the current release, SCOPe 2.08