SCOPe 2.08: Domain d2qk5a2: 2qk5 A:55-447

Lineage for d2qk5a2 (2qk5 A:55-447)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein beta-secretase (memapsin) [50671] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50672] (329 PDB entries)
   Uniprot P56817 58-446 ! Uniprot P56817 60-447

8. Domain d2qk5a2: 2qk5 A:55-447 [150837]
   Other proteins in same PDB: d2qk5a3
   automated match to d1fkna_
   complexed with cs5

Details for d2qk5a2

PDB Entry: 2qk5, 2.2 Å

PDB Description: structure of bace1 bound to sch626485

PDB Compounds: (A:) Beta-secretase 1

SCOPe Domain Sequences for d2qk5a2:

Sequence; same for both SEQRES and ATOM records:

>d2qk5a2 b.50.1.2 (A:55-447) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
grrgsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyq
rqlsstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffings
nwegilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggs
miiggidhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttn
lrlpkkvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtn
qsfritilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrig
favsachvhdefrtaavegpfvtldmedcgyni

Timeline for d2qk5a2:

• d2qk5a2 first appeared in SCOP 1.75, called d2qk5a1
  
• d2qk5a2 appears in SCOPe 2.07