SCOPe 2.01: Domain d2qb4a_: 2qb4 A:

Lineage for d2qb4a_ (2qb4 A:)

1. Root: SCOPe 2.01

2. Class f: Membrane and cell surface proteins and peptides [56835] (57 folds)

3. Fold f.54: SNF-like [161069] (1 superfamily)
   12 transmembrane helices; duplication: consists of two structurally similar halves

4. Superfamily f.54.1: SNF-like [161070] (1 family)

5. Family f.54.1.1: SNF-like [161071] (2 proteins)
   Pfam PF00209; Sodium:neurotransmitter symporter

6. Protein Na(+):neurotransmitter symporter homologue LeuT [161072] (1 species)

7. Species Aquifex aeolicus [TaxId:63363] [161073] (6 PDB entries)
   Uniprot O67854 5-513

8. Domain d2qb4a_: 2qb4 A: [150326]
   automated match to d2a65a1
   complexed with bog, dsm, leu, na

Details for d2qb4a_

PDB Entry: 2qb4, 1.9 Å

PDB Description: crystal structure analysis of leut complexed with l-leucine, sodium and desipramine

PDB Compounds: (A:) Transporter

SCOPe Domain Sequences for d2qb4a_:

Sequence, based on SEQRES records:

>d2qb4a_ f.54.1.1 (A:) Na(+):neurotransmitter symporter homologue LeuT {Aquifex aeolicus [TaxId: 63363]}
rehwatrlglilamagnavglgnflrfpvqaaengggafmipyiiafllvgiplmwiewa
mgryggaqghgttpaifyllwrnrfakilgvfglwiplvvaiyyvyieswtlgfaikflv
glvpepppnatdpdsilrpfkeflysyigvpkgdepilkpslfayivflitmfinvsili
rgiskgierfakiamptlfilavflvirvflletpngtaadglnflwtpdfeklkdpgvw
iaavgqifftlslgfgaiityasyvrkdqdivlsgltaatlnekaevilggsisipaava
ffgvanavaiakagafnlgfitlpaifsqtaggtflgflwffllffagltssiaimqpmi
afledelklsrkhavlwtaaivffsahlvmflnksldemdfwagtigvvffglteliiff
wifgadkaweeinrggiikvpriyyyvmryitpaflavllvvwareyipkimeethwtvw
itrfyiiglflfltflvflaerrrnhesagtl

Sequence, based on observed residues (ATOM records):

>d2qb4a_ f.54.1.1 (A:) Na(+):neurotransmitter symporter homologue LeuT {Aquifex aeolicus [TaxId: 63363]}
rehwatrlglilamagnavglgnflrfpvqaaengggafmipyiiafllvgiplmwiewa
mgryggaqghgttpaifyllwrnrfakilgvfglwiplvvaiyyvyieswtlgfaikflv
glvpeppptdpdsilrpfkeflysyigvpkgdepilkpslfayivflitmfinvsilirg
iskgierfakiamptlfilavflvirvflletpngtaadglnflwtpdfeklkdpgvwia
avgqifftlslgfgaiityasyvrkdqdivlsgltaatlnekaevilggsisipaavaff
gvanavaiakagafnlgfitlpaifsqtaggtflgflwffllffagltssiaimqpmiaf
ledelklsrkhavlwtaaivffsahlvmflnksldemdfwagtigvvffglteliiffwi
fgadkaweeinrggiikvpriyyyvmryitpaflavllvvwareyipkimeethwtvwit
rfyiiglflfltflvflaerrrnhesagtl

Timeline for d2qb4a_:

• d2qb4a_ first appeared in SCOP 1.75, called d2qb4a1
  
• d2qb4a_ appears in SCOPe 2.02
  
• d2qb4a_ appears in the current release, SCOPe 2.08, called d2qb4a2