SCOP 1.75: Domain d2q8ia1: 2q8i A:13-176

Lineage for d2q8ia1 (2q8i A:13-176)

1. Root: SCOP 1.75

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.29: Bromodomain-like [47363] (15 superfamilies)
   4 helices; bundle; minor mirror variant of up-and-down topology

4. Superfamily a.29.5: alpha-ketoacid dehydrogenase kinase, N-terminal domain [69012] (1 family)

5. Family a.29.5.1: alpha-ketoacid dehydrogenase kinase, N-terminal domain [69013] (2 proteins)

6. Protein Pyruvate dehydrogenase kinase [69016] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [158429] (5 PDB entries)
   Uniprot Q15120 13-176

8. Domain d2q8ia1: 2q8i A:13-176 [150126]
   Other proteins in same PDB: d2q8ia2, d2q8ib1
   automatically matched to 1Y8N A:13-176
   complexed with gol, k, rdc, red

Details for d2q8ia1

PDB Entry: 2q8i, 2.6 Å

PDB Description: pyruvate dehydrogenase kinase isoform 3 in complex with antitumor drug radicicol

PDB Compounds: (A:) [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3

SCOP Domain Sequences for d2q8ia1:

Sequence, based on SEQRES records:

>d2q8ia1 a.29.5.1 (A:13-176) Pyruvate dehydrogenase kinase {Human (Homo sapiens) [TaxId: 9606]}
pkqierysrfspsplsikqfldfgrdnacektsymflrkelpvrlantmrevnllpdnll
nrpsvglvqswymqsflelleyenkspedpqvldnflqvlikvrnrhndvvptmaqgvie
ykekfgfdpfistniqyfldrfytnrisfrmlinqhtllfggdt

Sequence, based on observed residues (ATOM records):

>d2q8ia1 a.29.5.1 (A:13-176) Pyruvate dehydrogenase kinase {Human (Homo sapiens) [TaxId: 9606]}
pkqierysrfspsplsikqfldfgrdnacektsymflrkelpvrlantmrevnllpdnll
nrpsvglvqswymqsflelleyenkspedpqvldnflqvlikvrnrhndvvptmaqgvie
ykekfgfdpfistniqyfldrfytnrisfrmlinqhtllfgt

Timeline for d2q8ia1:

• d2q8ia1 is new in SCOP 1.75
  
• d2q8ia1 appears in SCOPe 2.01
  
• d2q8ia1 appears in the current release, SCOPe 2.08