SCOPe 2.02: Domain d2q80e_: 2q80 E:

Lineage for d2q80e_ (2q80 E:)

1. Root: SCOPe 2.02

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.128: Terpenoid synthases [48575] (1 superfamily)
   multihelical; core: 8 helices (C-J) are arranged in 2 parallel layers

4. Superfamily a.128.1: Terpenoid synthases [48576] (6 families)
   duplication: two metal-binding sites are related by a pseudo dyad that also relates helices C-F to helices G-J

5. Family a.128.1.1: Isoprenyl diphosphate synthases [48577] (4 proteins)

6. Protein Geranylgeranyl pyrophosphate synthetase [158813] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [158814] (1 PDB entry)
   Uniprot O95749 6-296

8. Domain d2q80e_: 2q80 E: [150116]
   automated match to d2q80a1
   complexed with grg, mg

Details for d2q80e_

PDB Entry: 2q80, 2.7 Å

PDB Description: Crystal structure of human geranylgeranyl pyrophosphate synthase bound to GGPP

PDB Compounds: (E:) Geranylgeranyl pyrophosphate synthetase

SCOPe Domain Sequences for d2q80e_:

Sequence, based on SEQRES records:

>d2q80e_ a.128.1.1 (E:) Geranylgeranyl pyrophosphate synthetase {Human (Homo sapiens) [TaxId: 9606]}
etvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievtemlhnasllidd
iednsklrrgfpvahsiygipsvinsanyvyflglekvltldhpdavklftrqllelhqg
qgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedlkpllntlglffq
irddyanlhskeysenksfcedltegkfsfptihaiwsrpestqvqnilrqrtenidikk
ycvhyledvgsfeytrntlkeleakaykqidarggnpelvalvkhlskmf

Sequence, based on observed residues (ATOM records):

>d2q80e_ a.128.1.1 (E:) Geranylgeranyl pyrophosphate synthetase {Human (Homo sapiens) [TaxId: 9606]}
etvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievtemlhnasllidd
iednsklrrgfpvahsiygipsvinsanyvyflglekvltldhpdavklftrqllelhqg
qgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedlkpllntlglffq
irddyanlhsksfcedltegkfsfptihaiwsrpestqvqnilrqrtenidikkycvhyl
edvgsfeytrntlkeleakaykqidarggnpelvalvkhlskmf

Timeline for d2q80e_:

• d2q80e_ first appeared in SCOP 1.75, called d2q80e1
  
• d2q80e_ appears in SCOPe 2.01
  
• d2q80e_ appears in SCOPe 2.03
  
• d2q80e_ appears in the current release, SCOPe 2.08