SCOPe 2.08: Domain d2q72a2: 2q72 A:4-513

Lineage for d2q72a2 (2q72 A:4-513)

1. Root: SCOPe 2.08

2. Class f: Membrane and cell surface proteins and peptides [56835] (69 folds)

3. Fold f.54: SNF-like [161069] (1 superfamily)
   12 transmembrane helices; duplication: consists of two structurally similar halves

4. Superfamily f.54.1: SNF-like [161070] (3 families)

5. Family f.54.1.1: SNF-like [161071] (2 proteins)
   Pfam PF00209; Sodium:neurotransmitter symporter

6. Protein Na(+):neurotransmitter symporter homologue LeuT [161072] (1 species)

7. Species Aquifex aeolicus [TaxId:63363] [161073] (43 PDB entries)
   Uniprot O67854 5-513

8. Domain d2q72a2: 2q72 A:4-513 [150073]
   Other proteins in same PDB: d2q72a3
   automated match to d2a65a1
   complexed with bog, ixx, leu, na

Details for d2q72a2

PDB Entry: 2q72, 1.7 Å

PDB Description: crystal structure analysis of leut complexed with l-leucine, sodium, and imipramine

PDB Compounds: (A:) Transporter

SCOPe Domain Sequences for d2q72a2:

Sequence, based on SEQRES records:

>d2q72a2 f.54.1.1 (A:4-513) Na(+):neurotransmitter symporter homologue LeuT {Aquifex aeolicus [TaxId: 63363]}
krehwatrlglilamagnavglgnflrfpvqaaengggafmipyiiafllvgiplmwiew
amgryggaqghgttpaifyllwrnrfakilgvfglwiplvvaiyyvyieswtlgfaikfl
vglvpepppnatdpdsilrpfkeflysyigvpkgdepilkpslfayivflitmfinvsil
irgiskgierfakiamptlfilavflvirvflletpngtaadglnflwtpdfeklkdpgv
wiaavgqifftlslgfgaiityasyvrkdqdivlsgltaatlnekaevilggsisipaav
affgvanavaiakagafnlgfitlpaifsqtaggtflgflwffllffagltssiaimqpm
iafledelklsrkhavlwtaaivffsahlvmflnksldemdfwagtigvvffglteliif
fwifgadkaweeinrggiikvpriyyyvmryitpaflavllvvwareyipkimeethwtv
witrfyiiglflfltflvflaerrrnhesa

Sequence, based on observed residues (ATOM records):

>d2q72a2 f.54.1.1 (A:4-513) Na(+):neurotransmitter symporter homologue LeuT {Aquifex aeolicus [TaxId: 63363]}
krehwatrlglilamagnavglgnflrfpvqaaengggafmipyiiafllvgiplmwiew
amgryggaqghgttpaifyllwrnrfakilgvfglwiplvvaiyyvyieswtlgfaikfl
vglvpeppptdpdsilrpfkeflysyigvpkgdepilkpslfayivflitmfinvsilir
giskgierfakiamptlfilavflvirvflletpngtaadglnflwtpdfeklkdpgvwi
aavgqifftlslgfgaiityasyvrkdqdivlsgltaatlnekaevilggsisipaavaf
fgvanavaiakagafnlgfitlpaifsqtaggtflgflwffllffagltssiaimqpmia
fledelklsrkhavlwtaaivffsahlvmflnksldemdfwagtigvvffglteliiffw
ifgadkaweeinrggiikvpriyyyvmryitpaflavllvvwareyipkimeethwtvwi
trfyiiglflfltflvflaerrrnhesa

Timeline for d2q72a2:

• d2q72a2 first appeared in SCOP 1.75, called d2q72a1
  
• d2q72a2 appears in SCOPe 2.07