SCOPe 2.07: Domain d2q6ha2: 2q6h A:3-513

Lineage for d2q6ha2 (2q6h A:3-513)

1. Root: SCOPe 2.07

2. Class f: Membrane and cell surface proteins and peptides [56835] (60 folds)

3. Fold f.54: SNF-like [161069] (1 superfamily)
   12 transmembrane helices; duplication: consists of two structurally similar halves

4. Superfamily f.54.1: SNF-like [161070] (1 family)

5. Family f.54.1.1: SNF-like [161071] (2 proteins)
   Pfam PF00209; Sodium:neurotransmitter symporter

6. Protein Na(+):neurotransmitter symporter homologue LeuT [161072] (1 species)

7. Species Aquifex aeolicus [TaxId:63363] [161073] (43 PDB entries)
   Uniprot O67854 5-513

8. Domain d2q6ha2: 2q6h A:3-513 [150060]
   Other proteins in same PDB: d2q6ha3
   automated match to d2a65a1
   complexed with bog, cxx, leu, na

Details for d2q6ha2

PDB Entry: 2q6h, 1.85 Å

PDB Description: crystal structure analysis of leut complexed with l-leucine, sodium, and clomipramine

PDB Compounds: (A:) Transporter

SCOPe Domain Sequences for d2q6ha2:

Sequence, based on SEQRES records:

>d2q6ha2 f.54.1.1 (A:3-513) Na(+):neurotransmitter symporter homologue LeuT {Aquifex aeolicus [TaxId: 63363]}
vkrehwatrlglilamagnavglgnflrfpvqaaengggafmipyiiafllvgiplmwie
wamgryggaqghgttpaifyllwrnrfakilgvfglwiplvvaiyyvyieswtlgfaikf
lvglvpepppnatdpdsilrpfkeflysyigvpkgdepilkpslfayivflitmfinvsi
lirgiskgierfakiamptlfilavflvirvflletpngtaadglnflwtpdfeklkdpg
vwiaavgqifftlslgfgaiityasyvrkdqdivlsgltaatlnekaevilggsisipaa
vaffgvanavaiakagafnlgfitlpaifsqtaggtflgflwffllffagltssiaimqp
miafledelklsrkhavlwtaaivffsahlvmflnksldemdfwagtigvvffgltelii
ffwifgadkaweeinrggiikvpriyyyvmryitpaflavllvvwareyipkimeethwt
vwitrfyiiglflfltflvflaerrrnhesa

Sequence, based on observed residues (ATOM records):

>d2q6ha2 f.54.1.1 (A:3-513) Na(+):neurotransmitter symporter homologue LeuT {Aquifex aeolicus [TaxId: 63363]}
vkrehwatrlglilamagnavglgnflrfpvqaaengggafmipyiiafllvgiplmwie
wamgryggaqghgttpaifyllwrnrfakilgvfglwiplvvaiyyvyieswtlgfaikf
lvglvpeppptdpdsilrpfkeflysyigvpkgdepilkpslfayivflitmfinvsili
rgiskgierfakiamptlfilavflvirvflletpngtaadglnflwtpdfeklkdpgvw
iaavgqifftlslgfgaiityasyvrkdqdivlsgltaatlnekaevilggsisipaava
ffgvanavaiakagafnlgfitlpaifsqtaggtflgflwffllffagltssiaimqpmi
afledelklsrkhavlwtaaivffsahlvmflnksldemdfwagtigvvffglteliiff
wifgadkaweeinrggiikvpriyyyvmryitpaflavllvvwareyipkimeethwtvw
itrfyiiglflfltflvflaerrrnhesa

Timeline for d2q6ha2:

• d2q6ha2 first appeared in SCOP 1.75, called d2q6ha1
  
• d2q6ha2 appears in SCOPe 2.06
  
• d2q6ha2 appears in the current release, SCOPe 2.08