SCOPe 2.05: Domain d2pwra_: 2pwr A:

Lineage for d2pwra_ (2pwr A:)

1. Root: SCOPe 2.05

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.1: Retroviral protease (retropepsin) [50631] (9 proteins)
   dimer of identical mono-domain chains, each containing (6,10) barrel

6. Protein Human immunodeficiency virus type 1 protease [50632] (8 species)

7. Species Human immunodeficiency virus type 1 [TaxId:11676] [50633] (446 PDB entries)
   Uniprot P35963 57-155 ! Uniprot P04587 69-167 ! Uniprot P03366 69-167 ! Uniprot P03367 69-167 ! Uniprot P03368 69-167

8. Domain d2pwra_: 2pwr A: [149902]
   automated match to d1ajva_
   complexed with cl, g4g, gol

Details for d2pwra_

PDB Entry: 2pwr, 1.5 Å

PDB Description: HIV-1 protease in complex with a carbamoyl decorated pyrrolidine-based inhibitor

PDB Compounds: (A:) Gag-Pol polyprotein (Pr160Gag-Pol)

SCOPe Domain Sequences for d2pwra_:

Sequence; same for both SEQRES and ATOM records:

>d2pwra_ b.50.1.1 (A:) Human immunodeficiency virus type 1 protease {Human immunodeficiency virus type 1 [TaxId: 11676]}
pqitlwqrplvtikiggqlkealldtgaddtvleemslpgrwkpkmiggiggfikvrqyd
qilieicghkaigtvlvgptpvniigrnlltqigctlnf

Timeline for d2pwra_:

• d2pwra_ first appeared in SCOP 1.75, called d2pwra1
  
• d2pwra_ appears in SCOPe 2.04
  
• d2pwra_ appears in SCOPe 2.06
  
• d2pwra_ appears in the current release, SCOPe 2.08