Lineage for d2prma1 (2prm A:30-396)

  1. Root: SCOP 1.75
  2. 814173Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 814174Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
    contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
    the first seven superfamilies have similar phosphate-binding sites
  4. 814735Superfamily c.1.4: FMN-linked oxidoreductases [51395] (1 family) (S)
  5. 814736Family c.1.4.1: FMN-linked oxidoreductases [51396] (18 proteins)
  6. 814782Protein Dihydroorotate dehydrogenase [51397] (7 species)
  7. 814788Species Human (Homo sapiens) [TaxId:9606] [51400] (11 PDB entries)
  8. 814799Domain d2prma1: 2prm A:30-396 [149802]
    automatically matched to d1d3ga_
    complexed with fmn, oro; mutant

Details for d2prma1

PDB Entry: 2prm (more details), 3 Å

PDB Description: the structures of apo- and inhibitor bound human dihydroorotate dehydrogenase reveal conformational flexibility within the inhibitor binding site
PDB Compounds: (A:) Dihydroorotate dehydrogenase, mitochondrial

SCOP Domain Sequences for d2prma1:

Sequence; same for both SEQRES and ATOM records: (download)

>d2prma1 c.1.4.1 (A:30-396) Dihydroorotate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
matgderfyaehlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfr
npvgiaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygf
nshglsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladyl
vvnvsspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkedia
svvkelgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvp
iigvggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtda
igadhrr

SCOP Domain Coordinates for d2prma1:

Click to download the PDB-style file with coordinates for d2prma1.
(The format of our PDB-style files is described here.)

Timeline for d2prma1: