Lineage for d2prla_ (2prl A:)

  1. Root: SCOPe 2.08
  2. 2826024Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2826025Fold c.1: TIM beta/alpha-barrel [51350] (34 superfamilies)
    contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
    the first seven superfamilies have similar phosphate-binding sites
  4. 2827845Superfamily c.1.4: FMN-linked oxidoreductases [51395] (2 families) (S)
  5. 2827846Family c.1.4.1: FMN-linked oxidoreductases [51396] (19 proteins)
  6. 2827891Protein Dihydroorotate dehydrogenase [51397] (8 species)
  7. 2827897Species Human (Homo sapiens) [TaxId:9606] [51400] (69 PDB entries)
  8. 2827958Domain d2prla_: 2prl A: [149801]
    automated match to d1d3ga_
    complexed with act, ddq, fmn, oro, r2c, so4
    has additional subdomain(s) that are not in the common domain
    has additional insertions and/or extensions that are not grouped together

Details for d2prla_

PDB Entry: 2prl (more details), 2.1 Å

PDB Description: the structures of apo- and inhibitor bound human dihydroorotate dehydrogenase reveal conformational flexibility within the inhibitor binding site
PDB Compounds: (A:) Dihydroorotate dehydrogenase, mitochondrial

SCOPe Domain Sequences for d2prla_:

Sequence; same for both SEQRES and ATOM records: (download)

>d2prla_ c.1.4.1 (A:) Dihydroorotate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
matgderfyaehlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfr
npvgiaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygf
nshglsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladyl
vvnvsspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkedia
svvkelgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvp
iigvggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtda
igadhrr

SCOPe Domain Coordinates for d2prla_:

Click to download the PDB-style file with coordinates for d2prla_.
(The format of our PDB-style files is described here.)

Timeline for d2prla_: