SCOPe 2.08: Domain d2prha_: 2prh A:

Lineage for d2prha_ (2prh A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (34 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.4: FMN-linked oxidoreductases [51395] (2 families)

5. Family c.1.4.1: FMN-linked oxidoreductases [51396] (19 proteins)

6. Protein Dihydroorotate dehydrogenase [51397] (8 species)

7. Species Human (Homo sapiens) [TaxId:9606] [51400] (69 PDB entries)

8. Domain d2prha_: 2prh A: [149800]
   automated match to d1d3ga_
   complexed with 238, ddq, fmn, oro
   has additional subdomain(s) that are not in the common domain
   has additional insertions and/or extensions that are not grouped together

Details for d2prha_

PDB Entry: 2prh, 2.4 Å

PDB Description: the structures of apo- and inhibitor bound human dihydroorotate dehydrogenase reveal conformational flexibility within the inhibitor binding site

PDB Compounds: (A:) Dihydroorotate dehydrogenase, mitochondrial

SCOPe Domain Sequences for d2prha_:

Sequence, based on SEQRES records:

>d2prha_ c.1.4.1 (A:) Dihydroorotate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
matgderfyaehlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfr
npvgiaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygf
nshglsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladyl
vvnvsspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkedia
svvkelgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvp
iigvggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtda
igadhrr

Sequence, based on observed residues (ATOM records):

>d2prha_ c.1.4.1 (A:) Dihydroorotate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
matgderfyaehlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfr
npvgiaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygf
nshglsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladyl
vvnvsspgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvvkelgid
glivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiigvggvss
gqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaigadhrr

Timeline for d2prha_:

• d2prha_ first appeared in SCOP 1.75, called d2prha1
  
• d2prha_ appears in SCOPe 2.07