SCOPe 2.07: Domain d2poga_: 2pog A:

Lineage for d2poga_ (2pog A:)

1. Root: SCOPe 2.07

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Estrogen receptor alpha [48519] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48520] (82 PDB entries)
   Uniprot P03372 307-551

8. Domain d2poga_: 2pog A: [149721]
   automated match to d1qkta_
   complexed with wst

Details for d2poga_

PDB Entry: 2pog, 1.84 Å

PDB Description: benzopyrans as selective estrogen receptor b agonists (serbas). part 2: structure activity relationship studies on the benzopyran scaffold.

PDB Compounds: (A:) Estrogen receptor

SCOPe Domain Sequences for d2poga_:

Sequence, based on SEQRES records:

>d2poga_ a.123.1.1 (A:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
lalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvp
gfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveif
dmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdt
lihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvplydlllemld
ahrlh

Sequence, based on observed residues (ATOM records):

>d2poga_ a.123.1.1 (A:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
lalsltadqmvsalldaeppilyseyasmmglltnladrelvhminwakrvpgfvdltlh
dqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveifdmllatss
rfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdtlihlmaka
gltlqqqhqrlaqlllilshirhmsnkgmehlysmkvplydlllemldahrlh

Timeline for d2poga_:

• d2poga_ first appeared in SCOP 1.75, called d2poga1
  
• d2poga_ appears in SCOPe 2.06
  
• d2poga_ appears in the current release, SCOPe 2.08