SCOPe 2.06: Domain d2pnua_: 2pnu A:

Lineage for d2pnua_ (2pnu A:)

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Androgen receptor [63621] (4 species)

7. Species Human (Homo sapiens) [TaxId:9606] [63623] (62 PDB entries)
   Uniprot P10275 671-919

8. Domain d2pnua_: 2pnu A: [149706]
   automated match to d1e3ga_
   complexed with dtt, enm, mes, so4

Details for d2pnua_

PDB Entry: 2pnu, 1.65 Å

PDB Description: Crystal structure of human androgen receptor ligand-binding domain in complex with EM-5744

PDB Compounds: (A:) Androgen receptor

SCOPe Domain Sequences for d2pnua_:

Sequence, based on SEQRES records:

>d2pnua_ a.123.1.1 (A:) Androgen receptor {Human (Homo sapiens) [TaxId: 9606]}
qpiflnvleaiepgvvcaghdnnqpdsfaallsslnelgerqlvhvvkwakalpgfrnlh
vddqmaviqyswmglmvfamgwrsftnvnsrmlyfapdlvfneyrmhksrmysqcvrmrh
lsqefgwlqitpqeflcmkalllfsiipvdglknqkffdelrmnyikeldriiackrknp
tscsrrfyqltklldsvqpiarelhqftfdllikshmvsvdfpemmaeiisvqvpkilsg
kvkpiyfhtq

Sequence, based on observed residues (ATOM records):

>d2pnua_ a.123.1.1 (A:) Androgen receptor {Human (Homo sapiens) [TaxId: 9606]}
qpiflnvleaiepgvvcaghdnnqpdsfaallsslnelgerqlvhvvkwakalpgfrnlh
vddqmaviqyswmglmvfamgwrsftnvnsrmlyfapdlvfneyrmhksrmysqcvrmrh
lsqefgwlqitpqeflcmkalllfsiipvdglknqkffdelrmnyikeldriiactscsr
rfyqltklldsvqpiarelhqftfdllikshmvsvdfpemmaeiisvqvpkilsgkvkpi
yfhtq

Timeline for d2pnua_:

• d2pnua_ first appeared in SCOP 1.75, called d2pnua1
  
• d2pnua_ appears in SCOPe 2.05
  
• d2pnua_ appears in SCOPe 2.07
  
• d2pnua_ appears in the current release, SCOPe 2.08