SCOPe 2.01: Domain d2pnrf2: 2pnr F:177-301

Lineage for d2pnrf2 (2pnr F:177-301)

1. Root: SCOPe 2.01

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.122: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55873] (1 superfamily)
   8-stranded mixed beta-sheet; 2 layers: alpha/beta

4. Superfamily d.122.1: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55874] (4 families)

5. Family d.122.1.4: alpha-ketoacid dehydrogenase kinase, C-terminal domain [69804] (2 proteins)

6. Protein Pyruvate dehydrogenase kinase [69807] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [160702] (5 PDB entries)
   Uniprot Q15120 177-301

8. Domain d2pnrf2: 2pnr F:177-301 [149704]
   Other proteins in same PDB: d2pnra1, d2pnrb1, d2pnrc1, d2pnre1, d2pnrf1, d2pnrg1
   automatically matched to 1Y8N A:177-301
   complexed with red

Details for d2pnrf2

PDB Entry: 2pnr, 2.5 Å

PDB Description: Crystal Structure of the asymmetric Pdk3-l2 Complex

PDB Compounds: (F:) [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3

SCOPe Domain Sequences for d2pnrf2:

Sequence, based on SEQRES records:

>d2pnrf2 d.122.1.4 (F:177-301) Pyruvate dehydrogenase kinase {Human (Homo sapiens) [TaxId: 9606]}
npvhpkhigsidptcnvadvvkdayetakmlceqyylvapeleveefnakapdkpiqvvy
vpshlfhmlfelfknsmratvelyedrkegypavktlvtlgkedlsikisdlgggvplrk
idrlf

Sequence, based on observed residues (ATOM records):

>d2pnrf2 d.122.1.4 (F:177-301) Pyruvate dehydrogenase kinase {Human (Homo sapiens) [TaxId: 9606]}
npvhpkhigsidptcnvadvvkdayetakmlceqyylvapeleveefnakapdkpiqvvy
vpshlfhmlfelfknsmratvelyedypavktlvtlgkedlsikisdlgggvplrkidrl
f

Timeline for d2pnrf2:

• d2pnrf2 first appeared in SCOP 1.75
  
• d2pnrf2 appears in SCOPe 2.02
  
• d2pnrf2 appears in the current release, SCOPe 2.08