SCOPe 2.07: Domain d2phba_: 2phb A:

Lineage for d2phba_ (2phb A:)

1. Root: SCOPe 2.07

2. Class b: All beta proteins [48724] (178 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (49 proteins)

6. Protein Coagulation factor Xa, protease domain [50574] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50575] (57 PDB entries)
   Uniprot P00742 235-467

8. Domain d2phba_: 2phb A: [149464]
   Other proteins in same PDB: d2phbb_
   automated match to d1c5md_
   complexed with 230, ca

Details for d2phba_

PDB Entry: 2phb, 2.3 Å

PDB Description: an orally efficacious factor xa inhibitor

PDB Compounds: (A:) coagulation factor x, heavy chain

SCOPe Domain Sequences for d2phba_:

Sequence; same for both SEQRES and ATOM records:

>d2phba_ b.47.1.2 (A:) Coagulation factor Xa, protease domain {Human (Homo sapiens) [TaxId: 9606]}
ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmkt

Timeline for d2phba_:

• d2phba_ first appeared in SCOP 1.75, called d2phba1
  
• d2phba_ appears in SCOPe 2.06
  
• d2phba_ appears in the current release, SCOPe 2.08