SCOPe 2.07: Domain d2p4jc_: 2p4j C:

Lineage for d2p4jc_ (2p4j C:)

1. Root: SCOPe 2.07

2. Class b: All beta proteins [48724] (178 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein beta-secretase (memapsin) [50671] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50672] (329 PDB entries)
   Uniprot P56817 58-446 ! Uniprot P56817 60-447

8. Domain d2p4jc_: 2p4j C: [149212]
   automated match to d1fkna_
   complexed with 23i

Details for d2p4jc_

PDB Entry: 2p4j, 2.5 Å

PDB Description: crystal structure of beta-secretase bond to an inhibitor with isophthalamide derivatives at p2-p3

PDB Compounds: (C:) Beta-secretase 1

SCOPe Domain Sequences for d2p4jc_:

Sequence; same for both SEQRES and ATOM records:

>d2p4jc_ b.50.1.2 (C:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
gsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrql
sstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwe
gilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmii
ggidhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrl
pkkvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsf
ritilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfav
sachvhdefrtaavegpfvtldmedcgyn

Timeline for d2p4jc_:

• d2p4jc_ first appeared in SCOP 1.75, called d2p4jc1
  
• d2p4jc_ appears in SCOPe 2.06
  
• d2p4jc_ appears in the current release, SCOPe 2.08