SCOP 1.75: Domain d2p4jb1: 2p4j B:47P-385

Lineage for d2p4jb1 (2p4j B:47P-385)

1. Root: SCOP 1.75

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (3 families)

5. Family b.50.1.2: Pepsin-like [50646] (10 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein beta-secretase (memapsin) [50671] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50672] (51 PDB entries)
   Uniprot P56817 58-446
   Uniprot P56817 60-447
   Uniprot P56817 58-446 ! Uniprot P56817 60-447

8. Domain d2p4jb1: 2p4j B:47P-385 [149211]
   automatically matched to d1fkna_
   complexed with 23i

Details for d2p4jb1

PDB Entry: 2p4j, 2.5 Å

PDB Description: crystal structure of beta-secretase bond to an inhibitor with isophthalamide derivatives at p2-p3

PDB Compounds: (B:) Beta-secretase 1

SCOP Domain Sequences for d2p4jb1:

Sequence; same for both SEQRES and ATOM records:

>d2p4jb1 b.50.1.2 (B:47P-385) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
fvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlss
tyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwegi
lglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmiigg
idhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpk
kvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfri
tilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsa
chvhdefrtaavegpfvtldmedcgyn

Timeline for d2p4jb1:

• d2p4jb1 is new in SCOP 1.75
  
• d2p4jb1 is called d2p4jb_ in SCOPe 2.01
  
• d2p4jb1 appears in the current release, SCOPe 2.08, called d2p4jb_