SCOPe 2.05: Domain d2p40a_: 2p40 A:

Lineage for d2p40a_ (2p40 A:)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.66: S-adenosyl-L-methionine-dependent methyltransferases [53334] (1 superfamily)
   core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest

4. Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases [53335] (58 families)

5. Family c.66.1.25: mRNA cap methylase [88785] (3 proteins)

6. Protein An RNA cap (nucleoside-2'-O-)-methyltransferase domain of RNA polymerase NS5 [89741] (2 species)
   structurally and functionally similar to VP39

7. Species Flavivirus (Dengue virus type 2) [TaxId:12637] [89742] (8 PDB entries)
   Uniprot P12823 2495-2756

8. Domain d2p40a_: 2p40 A: [149192]
   automated match to d1l9ka_
   complexed with gtg, so4

Details for d2p40a_

PDB Entry: 2p40, 2.7 Å

PDB Description: Crystal Structure of Dengue Methyltransferase in Complex with 7MeGpppG

PDB Compounds: (A:) type II methyltransferase

SCOPe Domain Sequences for d2p40a_:

Sequence; same for both SEQRES and ATOM records:

>d2p40a_ c.66.1.25 (A:) An RNA cap (nucleoside-2'-O-)-methyltransferase domain of RNA polymerase NS5 {Flavivirus (Dengue virus type 2) [TaxId: 12637]}
etlgekwksrlnalgksefqiykksgiqevdrtlakegikrgetdhhavsrgsaklrwfv
ernlvtpegkvvdlgcgrggwsyycgglknvrevkgltkggpgheepipmstygwnlvrl
qsgvdvffippercdtllcdigesspnptveagrtlrvlnlvenwlsnntqfcvkvlnpy
mssviekmealqrkhggalvrnplsrnsthemywvsnasgnivssvnmisrmlinrftmr
hkkatyepdvdlgsgtrnigies

Timeline for d2p40a_:

• d2p40a_ first appeared in SCOP 1.75, called d2p40a1
  
• d2p40a_ appears in SCOPe 2.04
  
• d2p40a_ appears in SCOPe 2.06
  
• d2p40a_ appears in the current release, SCOPe 2.08