SCOPe 2.08: Domain d2oz2c_: 2oz2 C:

Lineage for d2oz2c_ (2oz2 C:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.3: Cysteine proteinases [54000] (1 superfamily)
   consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn

4. Superfamily d.3.1: Cysteine proteinases [54001] (24 families)
   the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet

5. Family d.3.1.1: Papain-like [54002] (26 proteins)

6. Protein Cruzain [54020] (1 species)

7. Species Trypanosoma cruzi [TaxId:5693] [54021] (29 PDB entries)

8. Domain d2oz2c_: 2oz2 C: [149098]
   automated match to d1ewla_
   complexed with d1r, so4

Details for d2oz2c_

PDB Entry: 2oz2, 1.95 Å

PDB Description: crystal structure analysis of cruzain bound to vinyl sulfone derived inhibitor (k11777)

PDB Compounds: (C:) Cruzipain

SCOPe Domain Sequences for d2oz2c_:

Sequence; same for both SEQRES and ATOM records:

>d2oz2c_ d.3.1.1 (C:) Cruzain {Trypanosoma cruzi [TaxId: 5693]}
apaavdwrargavtavkdqgqcgscwafsaignvecqwflaghpltnlseqmlvscdktd
sgcsgglmnnafewivqenngavytedsypyasgegisppcttsghtvgatitghvelpq
deaqiaawlavngpvavavdasswmtytggvmtscvseqldhgvllvgyndsaavpywii
knswttqwgeegyiriakgsnqclvkeeassavvg

Timeline for d2oz2c_:

• d2oz2c_ first appeared in SCOP 1.75, called d2oz2c1
  
• d2oz2c_ appears in SCOPe 2.07