SCOP 1.75: Domain d2ow3a1: 2ow3 A:35-384

Lineage for d2ow3a1 (2ow3 A:35-384)

1. Root: SCOP 1.75

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (7 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (63 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Glycogen synthase kinase-3 beta (Gsk3b) [69823] (1 species)
   CMGC group; GSK3 subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [69824] (16 PDB entries)
   Uniprot P49841 35-383
   Uniprot P49841 35-384
   Uniprot P49841 35-383 ! Uniprot P49841 35-384

8. Domain d2ow3a1: 2ow3 A:35-384 [149037]
   automatically matched to d1j1bb_
   complexed with bim

Details for d2ow3a1

PDB Entry: 2ow3, 2.8 Å

PDB Description: glycogen synthase kinase-3 beta in complex with bis-(indole)maleimide pyridinophane inhibitor

PDB Compounds: (A:) Glycogen synthase kinase-3 beta

SCOP Domain Sequences for d2ow3a1:

Sequence, based on SEQRES records:

>d2ow3a1 d.144.1.7 (A:35-384) Glycogen synthase kinase-3 beta (Gsk3b) {Human (Homo sapiens) [TaxId: 9606]}
skvttvvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikkvlqdkrfk
nrelqimrkldhcnivrlryffyssgekkdevylnlvldyvpetvyrvarhysrakqtlp
viyvklymyqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsakqlvrgepnv
syicsryyrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvdqlveiikvlg
tptreqiremnpnytefkfpqikahpwtkvfrprtppeaialcsrlleytptarltplea
cahsffdelrdpnvklpngrdtpalfnfttqelssnpplatilipphari

Sequence, based on observed residues (ATOM records):

>d2ow3a1 d.144.1.7 (A:35-384) Glycogen synthase kinase-3 beta (Gsk3b) {Human (Homo sapiens) [TaxId: 9606]}
skvttvvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikkvlqdkrfk
nrelqimrkldhcnivrlryffyskdevylnlvldyvpetvyrvarhysrakqtlpviyv
klymyqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsakqlvrgepnvsyic
sryyrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvdqlveiikvlgtptr
eqiremnpnytefkfpqikahpwtkvfrprtppeaialcsrlleytptarltpleacahs
ffdelrdpnvklpngrdtpalfnfttqelssnpplatilipphari

Timeline for d2ow3a1:

• d2ow3a1 is called d2ow3a_ in SCOPe 2.01
  
• d2ow3a1 appears in the current release, SCOPe 2.07, called d2ow3a_