Lineage for d2oipa2 (2oip A:181-521)

  1. Root: SCOP 1.75
  2. 849709Class d: Alpha and beta proteins (a+b) [53931] (376 folds)
  3. 871398Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
    contains large mixed beta-sheet
  4. 871399Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (1 family) (S)
  5. 871400Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (3 proteins)
  6. 871401Protein Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain [55841] (2 species)
  7. 871402Species Cryptosporidium hominis [TaxId:237895] [100887] (4 PDB entries)
  8. 871415Domain d2oipa2: 2oip A:181-521 [148785]
    Other proteins in same PDB: d2oipa1, d2oipb1, d2oipc1, d2oipd1, d2oipe1
    automatically matched to d1qzfa2
    complexed with cb3, mtx, ndp, ump; mutant

Details for d2oipa2

PDB Entry: 2oip (more details), 2.8 Å

PDB Description: crystal structure of the s290g active site mutant of ts-dhfr from cryptosporidium hominis
PDB Compounds: (A:) Chain A, crystal structure of Dhfr

SCOP Domain Sequences for d2oipa2:

Sequence, based on SEQRES records: (download)

>d2oipa2 d.117.1.1 (A:181-521) Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain {Cryptosporidium hominis [TaxId: 237895]}
ktlqncdpargqlksiddtvdllgeifgirkmgnrhkfpkeeiyntpsirfgrehyefqy
ldllsrvlengayrenrtgistysifgqmmrfdmresfpllttkkvairgifeeliwfik
gdtngnhliekkvyiwsgngskeyleriglghreendlgpiygfqwrhyngeyktmhddy
tgvgvdqlaklietlknnpkdrrhiltawnpsalsqmalppchvlsqyyvtndnclscnl
yqrscdlglgspfniasyailtmmlaqvcgyepgelaifigdahiyenhltqlkeqlsrt
prpfpqlkfkrkveniedfkwedieligyypyptikmdmav

Sequence, based on observed residues (ATOM records): (download)

>d2oipa2 d.117.1.1 (A:181-521) Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain {Cryptosporidium hominis [TaxId: 237895]}
kncdpargqlksiddtvdllgeifgirkmgnrhkfpkeeiyntpsirfgrehyefqyldl
lsrvlengayrenrtgistysifgqmmrfdmresfpllttkkvairgifeeliwfikgdt
ngnhliekkvyiwsgngskeyleriglghreendlgpiygfqwrhyngeyktmhddytgv
gvdqlaklietlknnpkdrrhiltawnpsalsqmalppchvlsqyyvtndnclscnlyqr
scdlglgspfniasyailtmmlaqvcgyepgelaifigdahiyenhltqlkeqlsrtprp
fpqlkfkrkveniedfkwedieligyypyptikmdmav

SCOP Domain Coordinates for d2oipa2:

Click to download the PDB-style file with coordinates for d2oipa2.
(The format of our PDB-style files is described here.)

Timeline for d2oipa2: