SCOPe 2.08: Domain d2k2ga2: 2k2g A:100-263

Lineage for d2k2ga2 (2k2g A:100-263)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.92: Zincin-like [55485] (2 superfamilies)
   contains mixed beta sheet with connection over free side of the sheet

4. Superfamily d.92.1: Metalloproteases ('zincins'), catalytic domain [55486] (18 families)

5. Family d.92.1.11: Matrix metalloproteases, catalytic domain [55528] (14 proteins)

6. Protein Macrophage elastase (MMP-12) [69780] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [69781] (58 PDB entries)
   Uniprot P39900 106-263 ! Uniprot P39900 106-264

8. Domain d2k2ga2: 2k2g A:100-263 [148260]
   Other proteins in same PDB: d2k2ga3
   automated match to d1hova_
   complexed with dsv, zn

Details for d2k2ga2

PDB Entry: 2k2g

PDB Description: solution structure of the wild-type catalytic domain of human matrix metalloproteinase 12 (mmp-12) in complex with a tight-binding inhibitor

PDB Compounds: (A:) Macrophage metalloelastase

SCOPe Domain Sequences for d2k2ga2:

Sequence; same for both SEQRES and ATOM records:

>d2k2ga2 d.92.1.11 (A:100-263) Macrophage elastase (MMP-12) {Human (Homo sapiens) [TaxId: 9606]}
frempggpvwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadi
lvvfargahgdfhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavhe
ighslglghssdpkavmfptykyvdintfrlsaddirgiqslyg

Timeline for d2k2ga2:

• d2k2ga2 first appeared in SCOP 1.75, called d2k2ga1
  
• d2k2ga2 was called d2k2ga_ in SCOPe 2.07