SCOPe 2.04: Domain d2jb6h2: 2jb6 H:121-221

Lineage for d2jb6h2 (2jb6 H:121-221)

1. Root: SCOPe 2.04

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (31 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 proteins)

6. Protein Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma [88574] (6 species)

7. Species Human (Homo sapiens) [TaxId:9606] [88575] (179 PDB entries)
   including humanized antibodies (chimeric proteins with human constant domains)
   Uniprot Q6N089 20-243 # 95% sequence identity; natural chimera: antibody heavy chain (Fab HYB3) ! SQ NA # humanized antibody ! Uniprot P01857 # IGHG1_HUMAN Ig gamma-1 chain C region ! SQ NA # engineered antibody

8. Domain d2jb6h2: 2jb6 H:121-221 [147960]
   Other proteins in same PDB: d2jb6a1, d2jb6a2, d2jb6b1, d2jb6h1, d2jb6l1, d2jb6l2
   automatically matched to d1ngzb2
   complexed with t5c

Details for d2jb6h2

PDB Entry: 2jb6, 2.85 Å

PDB Description: fab fragment in complex with small molecule hapten, crystal form-2

PDB Compounds: (H:) fab fragment mor03268 heavy chain

SCOPe Domain Sequences for d2jb6h2:

Sequence; same for both SEQRES and ATOM records:

>d2jb6h2 b.1.1.2 (H:121-221) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma {Human (Homo sapiens) [TaxId: 9606]}
astkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
glyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk

Timeline for d2jb6h2:

• d2jb6h2 first appeared in SCOP 1.75
  
• d2jb6h2 appears in SCOPe 2.03
  
• d2jb6h2 appears in SCOPe 2.05
  
• d2jb6h2 appears in the current release, SCOPe 2.08