SCOPe 2.03: Domain d2h8ha2: 2h8h A:141-246

Lineage for d2h8ha2 (2h8h A:141-246)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.93: SH2-like [55549] (1 superfamily)
   3 layers: a/b/a; antiparallel beta-sheet of 5 strands is flaked by two helices

4. Superfamily d.93.1: SH2 domain [55550] (2 families)

5. Family d.93.1.1: SH2 domain [55551] (35 proteins)
   Pfam PF00017

6. Protein c-src tyrosine kinase [55556] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [55557] (45 PDB entries)

8. Domain d2h8ha2: 2h8h A:141-246 [147241]
   Other proteins in same PDB: d2h8ha1, d2h8ha3
   automatically matched to d1hcsb_
   complexed with h8h

Details for d2h8ha2

PDB Entry: 2h8h, 2.2 Å

PDB Description: src kinase in complex with a quinazoline inhibitor

PDB Compounds: (A:) Proto-oncogene tyrosine-protein kinase Src

SCOPe Domain Sequences for d2h8ha2:

Sequence; same for both SEQRES and ATOM records:

>d2h8ha2 d.93.1.1 (A:141-246) c-src tyrosine kinase {Human (Homo sapiens) [TaxId: 9606]}
dsiqaeewyfgkitrreserlllnaenprgtflvresettkgayclsvsdfdnakglnvk
hykirkldsggfyitsrtqfnslqqlvayyskhadglchrlttvcp

Timeline for d2h8ha2:

• d2h8ha2 first appeared in SCOP 1.75
  
• d2h8ha2 appears in SCOPe 2.02
  
• d2h8ha2 appears in SCOPe 2.04
  
• d2h8ha2 appears in the current release, SCOPe 2.08