SCOPe 2.01: Domain d2elba1: 2elb A:6-273

Lineage for d2elba1 (2elb A:6-273)

1. Root: SCOPe 2.01

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.238: BAR/IMD domain-like [116747] (1 superfamily)
   6 helices, homodimer of 3-helical domains

4. Superfamily a.238.1: BAR/IMD domain-like [103657] (5 families)
   core: dimeric six-helical bundle; protuding long helices form aniparallel coiled coils at both bundle ends

5. Family a.238.1.1: BAR domain [103658] (4 proteins)
   sensor of membrane curvature

6. Protein DCC-interacting protein 13-alpha, APPL1 [158643] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [158644] (1 PDB entry)
   Uniprot Q9UKG1 6-273

8. Domain d2elba1: 2elb A:6-273 [146895]
   Other proteins in same PDB: d2elba2

Details for d2elba1

PDB Entry: 2elb, 2.6 Å

PDB Description: Crystal Structure of the BAR-PH domain of human APPL1

PDB Compounds: (A:) Adapter protein containing PH domain, PTB domain and leucine zipper motif 1

SCOPe Domain Sequences for d2elba1:

Sequence, based on SEQRES records:

>d2elba1 a.238.1.1 (A:6-273) DCC-interacting protein 13-alpha, APPL1 {Human (Homo sapiens) [TaxId: 9606]}
klpieetledspqtrsllgvfeedataisnymnqlyqamhriydaqnelsaathltskll
keyekqrfplggddevmsstlqqfskvidelsschavlstqladammfpitqfkerdlke
iltlkevfqiasndhdaainrysrlskkrendkvkyevtedvytsrkkqhqtmmhyfcal
ntlqykkkiallepllgymqaqisffkmgsenlneqleeflanigtsvqnvrremdsdie
tmqqtiedlevasdplyvpdpdptdfpv

Sequence, based on observed residues (ATOM records):

>d2elba1 a.238.1.1 (A:6-273) DCC-interacting protein 13-alpha, APPL1 {Human (Homo sapiens) [TaxId: 9606]}
klpieetledspqtrsllgvfeedataisnymnqlyqamhriydaqnelsaathltskll
keyekqrfpevmsstlqqfskvidelsschavlstqladammfpitqfkerdlkeiltlk
evfqiasndhdaainrysrlskkvkyevtedvytsrkkqhqtmmhyfcalntlqykkkia
llepllgymqaqisffkmgsenlneqleeflanigtsvqnvrremdsdietmqqtiedle
vasdplyvpdpdptdfpv

Timeline for d2elba1:

• d2elba1 first appeared in SCOP 1.75
  
• d2elba1 appears in SCOPe 2.02
  
• d2elba1 appears in the current release, SCOPe 2.08