SCOPe 2.03: Domain d2dw4a2: 2dw4 A:274-654,A:764-831

Lineage for d2dw4a2 (2dw4 A:274-654,A:764-831)

1. Root: SCOPe 2.03

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.3: FAD/NAD(P)-binding domain [51904] (1 superfamily)
   core: 3 layers, b/b/a; central parallel beta-sheet of 5 strands, order 32145; top antiparallel beta-sheet of 3 strands, meander

4. Superfamily c.3.1: FAD/NAD(P)-binding domain [51905] (8 families)

5. Family c.3.1.2: FAD-linked reductases, N-terminal domain [51913] (18 proteins)
   C-terminal domain is alpha+beta is common for the family

6. Protein Lysine-specific histone demethylase 1, LSD1 [159432] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [159433] (8 PDB entries)
   Uniprot O60341 274-654,764-836

8. Domain d2dw4a2: 2dw4 A:274-654,A:764-831 [146595]
   Other proteins in same PDB: d2dw4a1, d2dw4a3
   automatically matched to 2IW5 A:274-654,A:764-836
   complexed with fad

Details for d2dw4a2

PDB Entry: 2dw4, 2.3 Å

PDB Description: Crystal structure of human LSD1 at 2.3 A resolution

PDB Compounds: (A:) Lysine-specific histone demethylase 1

SCOPe Domain Sequences for d2dw4a2:

Sequence, based on SEQRES records:

>d2dw4a2 c.3.1.2 (A:274-654,A:764-831) Lysine-specific histone demethylase 1, LSD1 {Human (Homo sapiens) [TaxId: 9606]}
ptkktgkviiigsgvsglaaarqlqsfgmdvtlleardrvggrvatfrkgnyvadlgamv
vtglggnpmavvskqvnmelakikqkcplyeangqavpkekdemveqefnrlleatsyls
hqldfnvlnnkpvslgqalevviqlqekhvkdeqiehwkkivktqeelkellnkmvnlke
kikelhqqykeasevkpprditaeflvkskhrdltalckeydelaetqgkleeklqelea
nppsdvylssrdrqildwhfanlefanatplstlslkhwdqdddfeftgshltvrngysc
vpvalaegldiklntavrqvrytasgceviavntrstsqtfiykcdavlctlplgvlkqq
ppavqfvpplpewktsavqrmXvaagssgndydlmaqpitpgpsipgapqpiprlffage
htirnypatvhgallsglreagriadqflg

Sequence, based on observed residues (ATOM records):

>d2dw4a2 c.3.1.2 (A:274-654,A:764-831) Lysine-specific histone demethylase 1, LSD1 {Human (Homo sapiens) [TaxId: 9606]}
ptkktgkviiigsgvsglaaarqlqsfgmdvtlleardrvggrvatfrkgnyvadlgamv
vtglggnpmavvskqvnmelakikqkcplyeangqavpkekdemveqefnrlleatsyls
hqldfnvlnnkpvslgqalevviqlqekhvkdeqiehwkkivktqeelkellnkmvnlke
kikelhtaeflvkskhrdltalckeydelaetqgkleeklqeleanppsdvylssrdrqi
ldwhfanlefanatplstlslkhwdqdddfeftgshltvrngyscvpvalaegldiklnt
avrqvrytasgceviavntrstsqtfiykcdavlctlplgvlkqqppavqfvpplpewkt
savqrmXvaagssgndydlmaqpitppiprlffagehtirnypatvhgallsglreagri
adqflg

Timeline for d2dw4a2:

• d2dw4a2 first appeared in SCOP 1.75
  
• d2dw4a2 appears in SCOPe 2.02
  
• d2dw4a2 appears in SCOPe 2.04
  
• d2dw4a2 appears in the current release, SCOPe 2.08