SCOP 1.75: Domain d2dula1: 2dul A:3-377

Lineage for d2dula1 (2dul A:3-377)

1. Root: SCOP 1.75

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.66: S-adenosyl-L-methionine-dependent methyltransferases [53334] (1 superfamily)
   core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest

4. Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases [53335] (57 families)

5. Family c.66.1.58: TRM1-like [159697] (1 protein)
   Pfam PF02005; contains extra C-terminal alpha+beta subdomain

6. Protein N(2),N(2)-dimethylguanosine tRNA methyltransferase Trm1 [159698] (1 species)

7. Species Pyrococcus horikoshii [TaxId:53953] [159699] (4 PDB entries)
   Uniprot O59493 3-377

8. Domain d2dula1: 2dul A:3-377 [146588]
   complexed with gol; mutant

Details for d2dula1

PDB Entry: 2dul, 1.9 Å

PDB Description: Crystal structure of tRNA G26 methyltransferase Trm1 in apo form from Pyrococcus horikoshii

PDB Compounds: (A:) N(2),N(2)-dimethylguanosine tRNA methyltransferase

SCOP Domain Sequences for d2dula1:

Sequence, based on SEQRES records:

>d2dula1 c.66.1.58 (A:3-377) N(2),N(2)-dimethylguanosine tRNA methyltransferase Trm1 {Pyrococcus horikoshii [TaxId: 53953]}
lievqegkakilipkaesiydspvfynprmalnrdivvvllnilnpkivldalsatgirg
irfaletpaeevwlndisedayelmkrnvmlnfdgelreskgrailkgektivinhddan
rlmaerhryfhfidldpfgspmefldtalrsakrrgilgvtatdgaplcgahpraclrky
lavplrgelchevgtrilvgviaryaakydlgidvilayykdhyfrafvklkdgarkgde
tleklgyiyfddktgkfeleqgflptrpnaygpvwlgplkdekivskmvkeaeslslark
kqalkllkmidqeldiplfydthaigrrlkietkkveeiisalreqgyeatrthfsptgi
ktsapyevfietikr

Sequence, based on observed residues (ATOM records):

>d2dula1 c.66.1.58 (A:3-377) N(2),N(2)-dimethylguanosine tRNA methyltransferase Trm1 {Pyrococcus horikoshii [TaxId: 53953]}
lievqegkakilippvfynprmalnrdivvvllnilnpkivldalsatgirgirfaletp
aeevwlndisedayelmkrnvmlnfdgelreskgrailkgektivinhddanrlmaerhr
yfhfidldpfgspmefldtalrsakrrgilgvtatdgaplcgahpraclrkylavplrge
lchevgtrilvgviaryaakydlgidvilayykdhyfrafvklkdgarkgdetleklgyi
yfddktgkfeleqgflptrpnaygpvwlgplkdekivskmvkeaeslslarkkqalkllk
midqeldiplfydthaigrrlkietkkveeiisalreqgyeatrthfsptgiktsapyev
fietikr

Timeline for d2dula1:

• d2dula1 is new in SCOP 1.75
  
• d2dula1 appears in SCOPe 2.01
  
• d2dula1 appears in the current release, SCOPe 2.08