SCOP 1.75: Domain d2ciba1: 2cib A:5-449

Lineage for d2ciba1 (2cib A:5-449)

1. Root: SCOP 1.75

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.104: Cytochrome P450 [48263] (1 superfamily)
   multihelical

4. Superfamily a.104.1: Cytochrome P450 [48264] (1 family)

5. Family a.104.1.1: Cytochrome P450 [48265] (22 proteins)

6. Protein Cytochrome p450 14 alpha-sterol demethylase (cyp51) [48276] (1 species)

7. Species Mycobacterium tuberculosis [TaxId:1773] [48277] (9 PDB entries)
   Uniprot P0A512 P77901

8. Domain d2ciba1: 2cib A:5-449 [146398]
   automatically matched to d1x8va_
   complexed with cm6, hem; mutant

Details for d2ciba1

PDB Entry: 2cib, 1.5 Å

PDB Description: high throughput screening and x-ray crystallography assisted evaluation of small molecule scaffolds for cyp51 inhibitors

PDB Compounds: (A:) cytochrome p450 51

SCOP Domain Sequences for d2ciba1:

Sequence, based on SEQRES records:

>d2ciba1 a.104.1.1 (A:5-449) Cytochrome p450 14 alpha-sterol demethylase (cyp51) {Mycobacterium tuberculosis [TaxId: 1773]}
alprvsgghdehghleefrtdpiglmqrvrdelgdvgtfqlagkqvvllsgshanefffr
agdddldqakaypfmtpifgegvvfdasperrkemlhnaalrgeqmkghaatiedqvrrm
iadwgeageidlldffaeltiytssacligkkfrdqldgrfaklyhelergtdplayvdp
ylpiesfrrrdearnglvalvadimngrianpptdksdrdmldvliavkaetgtprfsad
eitgmfismmfaghhtssgtaswtlielmrhrdayaavideldelygdgrsvsfhalrqi
pqlenvlketlrlhppliilmrvakgefevqghrihegdlvaaspaisnripedfpdphd
fvparyeqprqedllnrwtwipfgagrhrcvgaafaimqikaifsvllreyefemaqppe
syrndhskmvvqlaqpaavryrrrt

Sequence, based on observed residues (ATOM records):

>d2ciba1 a.104.1.1 (A:5-449) Cytochrome p450 14 alpha-sterol demethylase (cyp51) {Mycobacterium tuberculosis [TaxId: 1773]}
alprvsgghdehghleefrtdpiglmqrvrdelgdvgtfqlagkqvvllsgshanefffr
agdddldqakaypfmtpifglrgeqmkghaatiedqvrrmiadwgeageidlldffaelt
iytssacligkkfrdqldgrfaklyhelergtdplayvdpylpiesfrrrdearnglval
vadimngrianpdrdmldvliavkaetgtprfsadeitgmfismmfaghhtssgtaswtl
ielmrhrdayaavideldelygdgrsvsfhalrqipqlenvlketlrlhppliilmrvak
gefevqghrihegdlvaaspaisnripedfpdphdfvparyeqprqedllnrwtwipfga
grhrcvgaafaimqikaifsvllreyefemaqppesyrndhskmvvqlaqpaavryrrrt

Timeline for d2ciba1:

• d2ciba1 is new in SCOP 1.75
  
• d2ciba1 is called d2ciba_ in SCOPe 2.01
  
• d2ciba1 appears in the current release, SCOPe 2.08, called d2ciba_