SCOPe 2.05: Domain d2bfba1: 2bfb A:6-400

Lineage for d2bfba1 (2bfb A:6-400)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

4. Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families)
   there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
   two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules

5. Family c.36.1.11: Branched-chain alpha-keto acid dehydrogenase PP module [88766] (5 proteins)
   parent family to TK and PFOR
   heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module

6. Protein Branched-chain alpha-keto acid dehydrogenase, PP module [88767] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [88768] (19 PDB entries)
   Uniprot P12694 52-445

8. Domain d2bfba1: 2bfb A:6-400 [146139]
   Other proteins in same PDB: d2bfbb1, d2bfbb2
   complexed with cl, gol, k, mn, mrd, tdp

Details for d2bfba1

PDB Entry: 2bfb, 1.77 Å

PDB Description: reactivity modulation of human branched-chain alpha-ketoacid dehydrogenase by an internal molecular switch

PDB Compounds: (A:) 2-oxoisovalerate dehydrogenase alpha subunit

SCOPe Domain Sequences for d2bfba1:

Sequence, based on SEQRES records:

>d2bfba1 c.36.1.11 (A:6-400) Branched-chain alpha-keto acid dehydrogenase, PP module {Human (Homo sapiens) [TaxId: 9606]}
kpqfpgasaefidklefiqpnvisgipiyrvmdrqgqiinpsedphlpkekvlklyksmt
llntmdrilyesqrqgrisfymtnygeegthvgsaaaldntdlvfgayreagvlmyrdyp
lelfmaqcygnisdlgkgrqmpvhygckerhfvtissplatqipqavgaayaakrananr
vvicyfgegaasegdahagfnfaatlecpiiffcrnngyaistptseqyrgdgiaargpg
ygimsirvdgndvfavynatkearrravaenqpflieamtyrighastsddssafrsvde
vnywdkqdhpisrlrhyllsqgwwdeeqekawrkqsrrkvmeafeqaerkpkpnpnllfs
dvyqempaqlrkqqeslarhlqtygehypldhfdk

Sequence, based on observed residues (ATOM records):

>d2bfba1 c.36.1.11 (A:6-400) Branched-chain alpha-keto acid dehydrogenase, PP module {Human (Homo sapiens) [TaxId: 9606]}
kpqfpgasaefidklefiqpnvisgipiyrvmdrqgqiinpsedphlpkekvlklyksmt
llntmdrilyesqrqgrisfymtnygeegthvgsaaaldntdlvfgayreagvlmyrdyp
lelfmaqcygnisdlgkgrqmpvhygckerhfvtissplatqipqavgaayaakrananr
vvicyfgegaasegdahagfnfaatlecpiiffcrnngyaistptseqyrgdgiaargpg
ygimsirvdgndvfavynatkearrravaenqpflieamtyrdhpisrlrhyllsqgwwd
eeqekawrkqsrrkvmeafeqaerkpkpnpnllfsdvyqempaqlrkqqeslarhlqtyg
ehypldhfdk

Timeline for d2bfba1:

• d2bfba1 first appeared in SCOP 1.75
  
• d2bfba1 appears in SCOPe 2.04
  
• d2bfba1 appears in SCOPe 2.06
  
• d2bfba1 appears in the current release, SCOPe 2.08