SCOP 1.75: Domain d2uxna2: 2uxn A:274-654,A:764-836

Lineage for d2uxna2 (2uxn A:274-654,A:764-836)

1. Root: SCOP 1.75

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.3: FAD/NAD(P)-binding domain [51904] (1 superfamily)
   core: 3 layers, b/b/a; central parallel beta-sheet of 5 strands, order 32145; top antiparallel beta-sheet of 3 strands, meander

4. Superfamily c.3.1: FAD/NAD(P)-binding domain [51905] (8 families)

5. Family c.3.1.2: FAD-linked reductases, N-terminal domain [51913] (18 proteins)
   C-terminal domain is alpha+beta is common for the family

6. Protein Lysine-specific histone demethylase 1, LSD1 [159432] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [159433] (8 PDB entries)
   Uniprot O60341 274-654,764-836

8. Domain d2uxna2: 2uxn A:274-654,A:764-836 [145761]
   Other proteins in same PDB: d2uxna1, d2uxna3, d2uxnb1
   automatically matched to 2IW5 A:274-654,A:764-836
   complexed with cl, fda, gol, lyp

Details for d2uxna2

PDB Entry: 2uxn, 2.72 Å

PDB Description: structural basis of histone demethylation by lsd1 revealed by suicide inactivation

PDB Compounds: (A:) Lysine-specific histone demethylase 1

SCOP Domain Sequences for d2uxna2:

Sequence; same for both SEQRES and ATOM records:

>d2uxna2 c.3.1.2 (A:274-654,A:764-836) Lysine-specific histone demethylase 1, LSD1 {Human (Homo sapiens) [TaxId: 9606]}
ptkktgkviiigsgvsglaaarqlqsfgmdvtlleardrvggrvatfrkgnyvadlgamv
vtglggnpmavvskqvnmelakikqkcplyeangqavpkekdemveqefnrlleatsyls
hqldfnvlnnkpvslgqalevviqlqekhvkdeqiehwkkivktqeelkellnkmvnlke
kikelhqqykeasevkpprditaeflvkskhrdltalckeydelaetqgkleeklqelea
nppsdvylssrdrqildwhfanlefanatplstlslkhwdqdddfeftgshltvrngysc
vpvalaegldiklntavrqvrytasgceviavntrstsqtfiykcdavlctlplgvlkqq
ppavqfvpplpewktsavqrmXvaagssgndydlmaqpitpgpsipgapqpiprlffage
htirnypatvhgallsglreagriadqflgamytl

Timeline for d2uxna2:

• d2uxna2 is new in SCOP 1.75
  
• d2uxna2 appears in SCOPe 2.01
  
• d2uxna2 appears in the current release, SCOPe 2.08