SCOPe 2.03: Domain d2ozla1: 2ozl A:1-361

Lineage for d2ozla1 (2ozl A:1-361)

1. Root: SCOPe 2.03

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

4. Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families)
   there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
   two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules

5. Family c.36.1.11: Branched-chain alpha-keto acid dehydrogenase PP module [88766] (5 proteins)
   parent family to TK and PFOR
   heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module

6. Protein E1-beta subunit of pyruvate dehydrogenase (PP module) [89651] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [89652] (5 PDB entries)

8. Domain d2ozla1: 2ozl A:1-361 [145744]
   Other proteins in same PDB: d2ozlb1, d2ozlb2, d2ozld1, d2ozld2
   complexed with k, mg, tpp

Details for d2ozla1

PDB Entry: 2ozl, 1.9 Å

PDB Description: human pyruvate dehydrogenase s264e variant

PDB Compounds: (A:) Pyruvate dehydrogenase E1 component alpha subunit, somatic form

SCOPe Domain Sequences for d2ozla1:

Sequence; same for both SEQRES and ATOM records:

>d2ozla1 c.36.1.11 (A:1-361) E1-beta subunit of pyruvate dehydrogenase (PP module) {Human (Homo sapiens) [TaxId: 9606]}
fandatfeikkcdlhrleegppvttvltredglkyyrmmqtvrrmelkadqlykqkiirg
fchlcdgqeaccvgleaginptdhlitayrahgftftrglsvreilaeltgrkggcakgk
ggsmhmyaknfyggngivgaqvplgagialackyngkdevcltlygdgaanqgqifeayn
maalwklpcificennrygmgtsveraaastdyykrgdfipglrvdgmdilcvreatrfa
aaycrsgkgpilmelqtyryhghemsdpgvsyrtreeiqevrsksdpimllkdrmvnsnl
asveelkeidvevrkeiedaaqfatadpeppleelgyhiyssdppfevrganqwikfksv
s

Timeline for d2ozla1:

• d2ozla1 first appeared in SCOP 1.75
  
• d2ozla1 appears in SCOPe 2.02
  
• d2ozla1 appears in SCOPe 2.04
  
• d2ozla1 appears in the current release, SCOPe 2.08