SCOPe 2.04: Domain d2iw8a1: 2iw8 A:1-297

Lineage for d2iw8a1 (2iw8 A:1-297)

1. Root: SCOPe 2.04

2. Class d: Alpha and beta proteins (a+b) [53931] (380 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88856] (340 PDB entries)
   Uniprot P24941

8. Domain d2iw8a1: 2iw8 A:1-297 [145544]
   Other proteins in same PDB: d2iw8b1, d2iw8b2, d2iw8c_, d2iw8d1, d2iw8d2
   complexed with 4sp, sgm; mutant

Details for d2iw8a1

PDB Entry: 2iw8, 2.3 Å

PDB Description: structure of human thr160-phospho cdk2-cyclin a f82h-l83v-h84d mutant with an o6-cyclohexylmethylguanine inhibitor

PDB Compounds: (A:) Cell division protein kinase 2

SCOPe Domain Sequences for d2iw8a1:

Sequence; same for both SEQRES and ATOM records:

>d2iw8a1 d.144.1.7 (A:1-297) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfehvdqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlr

Timeline for d2iw8a1:

• d2iw8a1 first appeared in SCOP 1.75
  
• d2iw8a1 appears in SCOPe 2.03
  
• d2iw8a1 appears in SCOPe 2.05
  
• d2iw8a1 appears in the current release, SCOPe 2.08