SCOPe 2.08: Domain d2iw5a2: 2iw5 A:274-654,A:764-836

Lineage for d2iw5a2 (2iw5 A:274-654,A:764-836)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.3: FAD/NAD(P)-binding domain [51904] (1 superfamily)
   core: 3 layers, b/b/a; central parallel beta-sheet of 5 strands, order 32145; top antiparallel beta-sheet of 3 strands, meander

4. Superfamily c.3.1: FAD/NAD(P)-binding domain [51905] (9 families)

5. Family c.3.1.2: FAD-linked reductases, N-terminal domain [51913] (18 proteins)
   C-terminal domain is alpha+beta is common for the family

6. Protein Lysine-specific histone demethylase 1, LSD1 [159432] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [159433] (27 PDB entries)
   Uniprot O60341 274-654,764-836

8. Domain d2iw5a2: 2iw5 A:274-654,A:764-836 [145540]
   Other proteins in same PDB: d2iw5a1, d2iw5a3, d2iw5b1, d2iw5b2
   includes the CoREST-binding subdomain (420-520), a long alpha-helical hairpin
   complexed with cl, fad, gol, nh4

Details for d2iw5a2

PDB Entry: 2iw5, 2.57 Å

PDB Description: structural basis for corest-dependent demethylation of nucleosomes by the human lsd1 histone demethylase

PDB Compounds: (A:) Lysine-specific histone demethylase 1

SCOPe Domain Sequences for d2iw5a2:

Sequence; same for both SEQRES and ATOM records:

>d2iw5a2 c.3.1.2 (A:274-654,A:764-836) Lysine-specific histone demethylase 1, LSD1 {Human (Homo sapiens) [TaxId: 9606]}
ptkktgkviiigsgvsglaaarqlqsfgmdvtlleardrvggrvatfrkgnyvadlgamv
vtglggnpmavvskqvnmelakikqkcplyeangqavpkekdemveqefnrlleatsyls
hqldfnvlnnkpvslgqalevviqlqekhvkdeqiehwkkivktqeelkellnkmvnlke
kikelhqqykeasevkpprditaeflvkskhrdltalckeydelaetqgkleeklqelea
nppsdvylssrdrqildwhfanlefanatplstlslkhwdqdddfeftgshltvrngysc
vpvalaegldiklntavrqvrytasgceviavntrstsqtfiykcdavlctlplgvlkqq
ppavqfvpplpewktsavqrmXvaagssgndydlmaqpitpgpsipgapqpiprlffage
htirnypatvhgallsglreagriadqflgamytl

Timeline for d2iw5a2:

• d2iw5a2 first appeared in SCOP 1.75
  
• d2iw5a2 appears in SCOPe 2.07