SCOPe 2.05: Domain d2hd5a1: 2hd5 A:211-521

Lineage for d2hd5a1 (2hd5 A:211-521)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.3: Cysteine proteinases [54000] (1 superfamily)
   consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn

4. Superfamily d.3.1: Cysteine proteinases [54001] (23 families)
   the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet

5. Family d.3.1.9: Ubiquitin carboxyl-terminal hydrolase, UCH [82568] (6 proteins)
   Pfam PF00443

6. Protein Ubiquitin carboxyl-terminal hydrolase 2, USP2 [159841] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [159842] (2 PDB entries)
   Uniprot O75604 263-600! Uniprot O75604 264-599

8. Domain d2hd5a1: 2hd5 A:211-521 [145293]
   Other proteins in same PDB: d2hd5b_
   complexed with zn

Details for d2hd5a1

PDB Entry: 2hd5, 1.85 Å

PDB Description: usp2 in complex with ubiquitin

PDB Compounds: (A:) Ubiquitin carboxyl-terminal hydrolase 2

SCOPe Domain Sequences for d2hd5a1:

Sequence, based on SEQRES records:

>d2hd5a1 d.3.1.9 (A:211-521) Ubiquitin carboxyl-terminal hydrolase 2, USP2 {Human (Homo sapiens) [TaxId: 9606]}
qglaglrnlgntcfmnsilqclsntrelrdyclqrlymrdlhhgsnahtalveefakliq
tiwtsspndvvspsefktqiqryaprfvgynqqdaqeflrflldglhnevnrvtlrpksn
penldhlpddekgrqmwrkyleredsrigdlfvgqlkssltctdcgycstvfdpfwdlsl
piakrgypevtlmdcmrlftkedvldgdekptccrcrgrkrcikkfsiqrfpkilvlhlk
rfsesrirtsklttfvnfplrdldlrefasentnhavynlyavsnhsgttmgghytaycr
spgtgewhtfndssvtpmsssqvrtsdayllfyela

Sequence, based on observed residues (ATOM records):

>d2hd5a1 d.3.1.9 (A:211-521) Ubiquitin carboxyl-terminal hydrolase 2, USP2 {Human (Homo sapiens) [TaxId: 9606]}
qglaglrnlgntcfmnsilqclsntrelrdyclqrlymrdgsnahtalveefakliqtiw
tsspndvvspsefktqiqryaprfvgynqqdaqeflrflldglhnevnrvhlpddekgrq
mwrkyleredsrigdlfvgqlkssltctdcgycstvfdpfwdlslpiavtlmdcmrlftk
edvldgdekptccrcrgrkrcikkfsiqrfpkilvlhlkrfsesrirtsklttfvnfplr
dldlrefasentnhavynlyavsnhsgttmgghytaycrspgtgewhtfndssvtpmsss
qvrtsdayllfyela

Timeline for d2hd5a1:

• d2hd5a1 first appeared in SCOP 1.75
  
• d2hd5a1 appears in SCOPe 2.04
  
• d2hd5a1 appears in SCOPe 2.06
  
• d2hd5a1 appears in the current release, SCOPe 2.08