SCOPe 2.06: Domain d2gk1a1: 2gk1 A:167-528

Lineage for d2gk1a1 (2gk1 A:167-528)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.8: (Trans)glycosidases [51445] (15 families)

5. Family c.1.8.6: beta-N-acetylhexosaminidase catalytic domain [51550] (6 proteins)
   Glycosyl hydrolase family 20, GH20
   automatically mapped to Pfam PF00728

6. Protein beta-hexosaminidase A [159387] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [159388] (2 PDB entries)
   Uniprot P06865 167-528

8. Domain d2gk1a1: 2gk1 A:167-528 [145210]
   Other proteins in same PDB: d2gk1a2, d2gk1b1, d2gk1b2, d2gk1c2, d2gk1d1, d2gk1d2, d2gk1e2, d2gk1f1, d2gk1f2, d2gk1g2, d2gk1h1, d2gk1h2
   automatically matched to 2GJX A:167-528
   complexed with ngt

Details for d2gk1a1

PDB Entry: 2gk1, 3.25 Å

PDB Description: x-ray crystal structure of ngt-bound hexa

PDB Compounds: (A:) Beta-hexosaminidase alpha chain

SCOPe Domain Sequences for d2gk1a1:

Sequence; same for both SEQRES and ATOM records:

>d2gk1a1 c.1.8.6 (A:167-528) beta-hexosaminidase A {Human (Homo sapiens) [TaxId: 9606]}
fphrgllldtsrhylplssildtldvmaynklnvfhwhlvddpsfpyesftfpelmrkgs
ynpvthiytaqdvkevieyarlrgirvlaefdtpghtlswgpgipglltpcysgsepsgt
fgpvnpslnntyefmstfflevssvfpdfylhlggdevdftcwksnpeiqdfmrkkgfge
dfkqlesfyiqtlldivssygkgyvvwqevfdnkvkiqpdtiiqvwredipvnymkelel
vtkagfrallsapwylnrisygpdwkdfyvveplafegtpeqkalviggeacmwgeyvdn
tnlvprlwpragavaerlwsnkltsdltfayerlshfrcellrrgvqaqplnvgfceqef
eq

Timeline for d2gk1a1:

• d2gk1a1 first appeared in SCOP 1.75
  
• d2gk1a1 appears in SCOPe 2.05
  
• d2gk1a1 does not appear in SCOPe 2.07