SCOPe 2.08: Domain d2gafd_: 2gaf D:

Lineage for d2gafd_ (2gaf D:)

1. Root: SCOPe 2.08

2. Class e: Multi-domain proteins (alpha and beta) [56572] (74 folds)

3. Fold e.69: Poly(A) polymerase catalytic subunit-like [160956] (1 superfamily)
   3 domains; d1: all-alpha, contains HhH motif; d2: alpha+beta of nucleotidyltransferase fold (81302); d3: [alpha+beta; beta(3)-alpha-beta(3)-alpha(2); 3 layers: a/b/a; mixed beta-sheet of 6 strands, order 123654, strands 2 and 5 are antiparallel to the rest

4. Superfamily e.69.1: Poly(A) polymerase catalytic subunit-like [160957] (1 family)
   Central domain d2 is distantly related to the nucleotidyltransferase superfamily (81301)

5. Family e.69.1.1: Poxvirus poly(A) polymerase catalytic subunit-like [160958] (2 proteins)
   Pfam PF03296

6. Protein Poly(A) polymerase catalytic subunit, PAPL [160959] (1 species)

7. Species Vaccinia virus [TaxId:10245] [160960] (2 PDB entries)
   Uniprot P23371 12-479

8. Domain d2gafd_: 2gaf D: [145191]
   Other proteins in same PDB: d2gafa_
   automated match to d2ga9d1

Details for d2gafd_

PDB Entry: 2gaf, 2.4 Å

PDB Description: crystal structure of the vaccinia polyadenylate polymerase heterodimer (apo form)

PDB Compounds: (D:) Poly(A) polymerase catalytic subunit

SCOPe Domain Sequences for d2gafd_:

Sequence, based on SEQRES records:

>d2gafd_ e.69.1.1 (D:) Poly(A) polymerase catalytic subunit, PAPL {Vaccinia virus [TaxId: 10245]}
nitlkiietylgrvpsvneyhmlksqarniqkitvfnkdifvslvkknkkrffsdvntsa
seikdrilsyfskqtqtynigklftiielqsvlvttytdilgvltikapnvisskisynv
tsmeelardmlnsmnvavidkakvmgrhnvsslvknvnklmeeylrrhnkscicygsysl
ylinpnirygdidilqtnsrtflidlaflikfitgnniilskipylrnymvikdendnhi
idsfnirqdtmnvvpkifidniyivdptfqllnmikmfsqidrledlskdpekfnarmat
mleyvrythgivfdgkrnnmpmkciidennrivtvttkdyfsfkkclvyldenvlssdil
dlnadtscdfesvtnsvylihdnimytyfsntillsdkgkvheisarglcahillyqmlt
sgeykqclsdllnsmmnrdkipiyshterdkkpgrhgfiniekdiivf

Sequence, based on observed residues (ATOM records):

>d2gafd_ e.69.1.1 (D:) Poly(A) polymerase catalytic subunit, PAPL {Vaccinia virus [TaxId: 10245]}
nitlkiietylgrvpsvneyhmlksqarniqkitvfnkdifvslvkknkkrffsdvntsa
seikdrilsyfskqtqtynigklftiielqsvlvttytdilgvltikaptsmeelardml
nsmnvavivsslvknvnklmeeylrrhnkscicygsyslylinpnirygdidilqtnsrt
flidlaflikfitgnniilskipylrnymvikdendnhiidsfnirqdtmnvvpkifidn
iyivdptfqllnmikmfsqidrledlskdpekfnarmatmleyvrythgivfdgkrnnmp
mkciidennrivtvttkdyfsfkkclvyldenvlssdildlnadtscdfesvtnsvylih
dnimytyfsntillsdkgkvheisarglcahillyqmltsgeykqclsdllnsmmnrdki
piyshterdkkpgrhgfiniekdiivf

Timeline for d2gafd_:

• d2gafd_ first appeared in SCOP 1.75, called d2gafd1
  
• d2gafd_ appears in SCOPe 2.07