SCOPe 2.08: Domain d2fjub4: 2fju B:312-660

Lineage for d2fjub4 (2fju B:312-660)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (34 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.18: PLC-like phosphodiesterases [51695] (4 families)

5. Family c.1.18.1: Mammalian PLC [51696] (2 proteins)

6. Protein Phospholipase C-beta-2 [159421] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [159422] (2 PDB entries)
   Uniprot Q00722 312-660

8. Domain d2fjub4: 2fju B:312-660 [145173]
   Other proteins in same PDB: d2fjua_, d2fjub1, d2fjub2, d2fjub3
   complexed with ca, gsp, mg

Details for d2fjub4

PDB Entry: 2fju, 2.2 Å

PDB Description: Activated Rac1 bound to its effector phospholipase C beta 2

PDB Compounds: (B:) 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2

SCOPe Domain Sequences for d2fjub4:

Sequence, based on SEQRES records:

>d2fjub4 c.1.18.1 (B:312-660) Phospholipase C-beta-2 {Human (Homo sapiens) [TaxId: 9606]}
hdmtqplnhyfinsshntyltagqfsglssaemyrqvllsgcrcveldcwkgkppdeepi
ithgftmttdiffkeaieaiaesafktspypiilsfenhvdsprqqakmaeycrtifgdm
llteplekfplkpgvplpspedlrgkiliknkknqfsgptssskdtggeaegssppsapa
vwageegteleeeeveeeeeeesgnldeeeikkmqsdegtaglevtayeemsslvnyiqp
tkfvsfefsaqknrsyvissftelkaydllskasvqfvdynkrqmsriypkgtrmdssny
mpqmfwnagcqmvalnfqtmdlpmqqnmavfefngqsgyllkhefmrrp

Sequence, based on observed residues (ATOM records):

>d2fjub4 c.1.18.1 (B:312-660) Phospholipase C-beta-2 {Human (Homo sapiens) [TaxId: 9606]}
hdmtqplnhyfinsshntyltagqfsglssaemyrqvllsgcrcveldcwkgkppdeepi
ithgftmttdiffkeaieaiaesafktspypiilsfenhvdsprqqakmaeycrtifgdm
llteplekfplkpgvplpspedlrgkiliknkkeesgnldeeeikkmqsdegtaglevta
yeemsslvnyiqptkfvsfefsaqknrsyvissftelkaydllskasvqfvdynkrqmsr
iypkgtrmdssnympqmfwnagcqmvalnfqtmdlpmqqnmavfefngqsgyllkhefmr
rp

Timeline for d2fjub4:

• d2fjub4 first appeared in SCOP 1.75
  
• d2fjub4 appears in SCOPe 2.07