Lineage for d1y8xb1 (1y8x B:349-440)

  1. Root: SCOP 1.75
  2. 814173Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 848423Fold c.111: Activating enzymes of the ubiquitin-like proteins [69571] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 32145678; strands 6 and 8 are antiparallel to the rest
  4. 848424Superfamily c.111.1: Activating enzymes of the ubiquitin-like proteins [69572] (2 families) (S)
    transfer adenylyl group to the C-terminal carboxyl group of the ubiquitin and MoaD/ThiS-related proteins
    the ATP nucleotide-binding site is similar to that of the NAD-binding Rossmann-folds
  5. 848431Family c.111.1.2: Ubiquitin activating enzymes (UBA) [89763] (2 proteins)
    the common fold is elaborated with additional (sub)domains
  6. 848459Protein UBA3 [89764] (1 species)
    a subunit of the heterodimeric E1 enzyme for NEDD8; contains an all-alpha insert subdomain of the FF-like fold (residues 210-288) and an extra C-terminal alpha+beta subdomain (partly disordered)
  7. 848460Species Human (Homo sapiens) [TaxId:9606] [89765] (7 PDB entries)
    Uniprot Q8TBC4 33-458
  8. 848463Domain d1y8xb1: 1y8x B:349-440 [144607]
    Other proteins in same PDB: d1y8xa1
    C-terminal, E2 binding domain only; (this domain belongs to Pfam PF08825)

Details for d1y8xb1

PDB Entry: 1y8x (more details), 2.4 Å

PDB Description: structural basis for recruitment of ubc12 by an e2-binding domain in nedd8's e1
PDB Compounds: (B:) ubiquitin-activating enzyme E1C

SCOP Domain Sequences for d1y8xb1:

Sequence; same for both SEQRES and ATOM records: (download)

>d1y8xb1 c.111.1.2 (B:349-440) UBA3 {Human (Homo sapiens) [TaxId: 9606]}

SCOP Domain Coordinates for d1y8xb1:

Click to download the PDB-style file with coordinates for d1y8xb1.
(The format of our PDB-style files is described here.)

Timeline for d1y8xb1:

View in 3D
Domains from other chains:
(mouse over for more information)