Lineage for Protein: Poly [ADP-ribose] polymerase-1, PARP-1

1. Root: SCOP 1.73

2. Class d: Alpha and beta proteins (a+b) [53931] (334 folds)

3. Fold d.297: WGR domain-like [142920] (1 superfamily) beta(4)-alpha-X-beta; 2 layers, a/b; antiparallel beta-sheet, order 51234; the beta-hairpin insetrion in strand 1 results in the formation of a beta-triangle structure

4. Superfamily d.297.1: WGR domain-like [142921] (1 family)

5. Family d.297.1.1: WGR domain [142922] (1 protein) Pfam PF05406; the conserved WGR motif maps to the C-end of strand 3, both large sidechains are exposed

6. Protein Poly [ADP-ribose] polymerase-1, PARP-1 [142923] (1 species)