SCOPe 2.07: Species: Human (Homo sapiens) [TaxId: 9606]

Lineage for Species: Human (Homo sapiens) [TaxId: 9606]

Root: SCOPe 2.07
Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
The nucleotide-binding modes of this and the next two folds/superfamilies are similar

Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
also known as short-chain dehydrogenases and SDR family
parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

Protein Sepiapterin reductase [51767] (2 species)
Species Human (Homo sapiens) [TaxId:9606] [141874] (14 PDB entries)
Uniprot P35270 5-261

PDB entries in Species: Human (Homo sapiens) [TaxId: 9606]:

Domain(s) for 1z6z:
1. Domain d1z6za1: 1z6z A:2-258 [124575]
  Other proteins in same PDB: d1z6za2, d1z6zb3, d1z6zc3, d1z6zd3, d1z6ze3, d1z6zf3
  complexed with cl, nap, so4
2. Domain d1z6zb2: 1z6z B:2-258 [124576]
  Other proteins in same PDB: d1z6za2, d1z6zb3, d1z6zc3, d1z6zd3, d1z6ze3, d1z6zf3
  automated match to d1z6za1
  complexed with cl, nap, so4
3. Domain d1z6zc2: 1z6z C:2-258 [124577]
  Other proteins in same PDB: d1z6za2, d1z6zb3, d1z6zc3, d1z6zd3, d1z6ze3, d1z6zf3
  automated match to d1z6za1
  complexed with cl, nap, so4
4. Domain d1z6zd2: 1z6z D:2-258 [124578]
  Other proteins in same PDB: d1z6za2, d1z6zb3, d1z6zc3, d1z6zd3, d1z6ze3, d1z6zf3
  automated match to d1z6za1
  complexed with cl, nap, so4
5. Domain d1z6ze2: 1z6z E:2-258 [124579]
  Other proteins in same PDB: d1z6za2, d1z6zb3, d1z6zc3, d1z6zd3, d1z6ze3, d1z6zf3
  automated match to d1z6za1
  complexed with cl, nap, so4
6. Domain d1z6zf2: 1z6z F:2-258 [124580]
  Other proteins in same PDB: d1z6za2, d1z6zb3, d1z6zc3, d1z6zd3, d1z6ze3, d1z6zf3
  automated match to d1z6za1
  complexed with cl, nap, so4
Domain(s) for 4hwk:
1. Domain d4hwka_: 4hwk A: [252530]
  automated match to d1z6za1
  complexed with gol, nap, peg, sfy, so4
2. Domain d4hwkb_: 4hwk B: [252531]
  automated match to d1z6za1
  complexed with gol, nap, peg, sfy, so4
3. Domain d4hwkc_: 4hwk C: [252532]
  automated match to d1z6za1
  complexed with gol, nap, peg, sfy, so4
4. Domain d4hwkd_: 4hwk D: [252533]
  automated match to d1z6za1
  complexed with gol, nap, peg, sfy, so4
Domain(s) for 4j7u:
1. Domain d4j7ua_: 4j7u A: [252835]
  automated match to d1z6za1
  complexed with gol, nap, peg, so4, ytz
2. Domain d4j7ub_: 4j7u B: [252836]
  automated match to d1z6za1
  complexed with gol, nap, peg, so4, ytz
3. Domain d4j7uc_: 4j7u C: [252837]
  automated match to d1z6za1
  complexed with gol, nap, peg, so4, ytz
4. Domain d4j7ud_: 4j7u D: [252838]
  automated match to d1z6za1
  complexed with gol, nap, peg, so4, ytz
Domain(s) for 4j7x:
1. Domain d4j7xa_: 4j7x A: [252839]
  automated match to d1z6za1
  complexed with gol, nap, peg, sas, so4
2. Domain d4j7xb_: 4j7x B: [252840]
  automated match to d1z6za1
  complexed with gol, nap, peg, sas, so4
3. Domain d4j7xf_: 4j7x F: [252841]
  automated match to d1z6za1
  complexed with gol, nap, peg, sas, so4
4. Domain d4j7xj_: 4j7x J: [252842]
  automated match to d1z6za1
  complexed with gol, nap, peg, sas, so4
Domain(s) for 4xwy:
1. Domain d4xwya_: 4xwy A: [274553]
  automated match to d1z6zb_
  complexed with 43o, ndp, so4
2. Domain d4xwyb_: 4xwy B: [274554]
  automated match to d1z6zb_
  complexed with 43o, ndp, so4
3. Domain d4xwyc_: 4xwy C: [274555]
  automated match to d1z6zb_
  complexed with 43o, ndp, so4
4. Domain d4xwyd_: 4xwy D: [274556]
  automated match to d1z6zb_
  complexed with 43o, ndp, so4
Domain(s) for 4z3k:
1. Domain d4z3ka_: 4z3k A: [279521]
  automated match to d1z6zb_
  complexed with 4kl, edo, nap, so4
2. Domain d4z3kb_: 4z3k B: [279520]
  automated match to d1z6zb_
  complexed with 4kl, edo, nap, so4
3. Domain d4z3kc_: 4z3k C: [279518]
  automated match to d1z6zb_
  complexed with 4kl, edo, nap, so4
4. Domain d4z3kd_: 4z3k D: [279519]
  automated match to d1z6zb_
  complexed with 4kl, edo, nap, so4
Domain(s) for 6i6c:
1. Domain d6i6ca1: 6i6c A:1-260 [370262]
  Other proteins in same PDB: d6i6ca2
  automated match to d4hwka_
  complexed with edo, h4h, nap
2. Domain d6i6cb_: 6i6c B: [370244]
  Other proteins in same PDB: d6i6ca2
  automated match to d4hwka_
  complexed with edo, h4h, nap
Domain(s) for 6i6f:
1. Domain d6i6fa1: 6i6f A:1-260 [370224]
  Other proteins in same PDB: d6i6fa2
  automated match to d4hwka_
  complexed with edo, h4e, nap
2. Domain d6i6fb_: 6i6f B: [370260]
  Other proteins in same PDB: d6i6fa2
  automated match to d4hwka_
  complexed with edo, h4e, nap
Domain(s) for 6i6p:
1. Domain d6i6pa1: 6i6p A:1-261 [370239]
  Other proteins in same PDB: d6i6pa2
  automated match to d4hwka_
  complexed with edo, h4t, nap
2. Domain d6i6pb_: 6i6p B: [370270]
  Other proteins in same PDB: d6i6pa2
  automated match to d4hwka_
  complexed with edo, h4t, nap
Domain(s) for 6i6t:
1. Domain d6i6ta_: 6i6t A: [370261]
  automated match to d4hwka_
  complexed with edo, h5b, nap
2. Domain d6i6tb_: 6i6t B: [370193]
  automated match to d4hwka_
  complexed with edo, h5b, nap
Domain(s) for 6i6v:
1. Domain d6i6va1: 6i6v A:1-260 [370204]
  Other proteins in same PDB: d6i6va2
  automated match to d4hwka_
  complexed with edo, h6e, nap
2. Domain d6i6vb_: 6i6v B: [370191]
  Other proteins in same PDB: d6i6va2
  automated match to d4hwka_
  complexed with edo, h6e, nap
Domain(s) for 6i79:
1. Domain d6i79a1: 6i79 A:1-261 [370254]
  Other proteins in same PDB: d6i79a2, d6i79b2
  automated match to d4hwka_
  complexed with h5e, nap
2. Domain d6i79b1: 6i79 B:1-261 [370281]
  Other proteins in same PDB: d6i79a2, d6i79b2
  automated match to d4hwka_
  complexed with h5e, nap
Domain(s) for 6usn:
1. Domain d6usna_: 6usn A: [378166]
  automated match to d4hwka_
  complexed with gol, nap, peg, qgv, so4
2. Domain d6usnb_: 6usn B: [378155]
  automated match to d4hwka_
  complexed with gol, nap, peg, qgv, so4
3. Domain d6usnc_: 6usn C: [378145]
  automated match to d4hwka_
  complexed with gol, nap, peg, qgv, so4
4. Domain d6usnd_: 6usn D: [378146]
  automated match to d4hwka_
  complexed with gol, nap, peg, qgv, so4
Domain(s) for 7dsf:
1. Domain d7dsfa_: 7dsf A: [398920]
  automated match to d4hwka_
  complexed with act, nap, zn
2. Domain d7dsfb_: 7dsf B: [398955]
  automated match to d4hwka_
  complexed with act, nap, zn

More info for Species Human (Homo sapiens) [TaxId:9606] from c.2.1.2 Sepiapterin reductase

Timeline for Species Human (Homo sapiens) [TaxId:9606] from c.2.1.2 Sepiapterin reductase:

Species Human (Homo sapiens) [TaxId:9606] from c.2.1.2 Sepiapterin reductase first appeared in SCOP 1.73
Species Human (Homo sapiens) [TaxId:9606] from c.2.1.2 Sepiapterin reductase appears in SCOPe 2.06
Species Human (Homo sapiens) [TaxId:9606] from c.2.1.2 Sepiapterin reductase appears in the current release, SCOPe 2.08