SCOP 1.75: Family a.60.2.5: Hef domain-like

Lineage for Family a.60.2.5: Hef domain-like

1. Root: SCOP 1.75

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.60: SAM domain-like [47768] (16 superfamilies)
   4-5 helices; bundle of two orthogonally packed alpha-hairpins; involved in the interactions with DNA and proteins

4. Superfamily a.60.2: RuvA domain 2-like [47781] (7 families)
   duplication: contains two helix-hairpin-helix (HhH) motifs

5. Family a.60.2.5: Hef domain-like [140629] (3 proteins)
   helicase/nuclease domain; forms homo and heterodimers; probably includes the Excinuclease UvrC C-terminal domain ((81795), that contains a single NMR structure of a monomeric truncated domain, 1kft)
   helicase/nuclease domain; forms homo and heterodimers; probably includes the Excinuclease UvrC C-terminal domain ((81795), that contains a single NMR structure of a monomeric truncated domain, 1kft)

Proteins:

1. ATP-dependent RNA helicase PF2015 [140632] (1 species)

   • Species Pyrococcus furiosus [TaxId:2261] [140633] (1 PDB entry)
     Uniprot Q8TZH8 694-761

2. DNA excision repair protein ERCC-1 [140630] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [140631] (2 PDB entries)
     Uniprot P07992 219-296! Uniprot P07992 220-297

3. DNA repair endonuclease XPF [140634] (2 species)

   1. Species Aeropyrum pernix [TaxId:56636] [140635] (2 PDB entries)
      Uniprot Q9YC15 160-229

   2. Species Human (Homo sapiens) [TaxId:9606] [140636] (3 PDB entries)
      Uniprot Q92889 823-905! Uniprot Q92889 837-898

More info for Family a.60.2.5: Hef domain-like

Timeline for Family a.60.2.5: Hef domain-like:

• Family a.60.2.5: Hef domain-like first appeared in SCOP 1.73
  
• Family a.60.2.5: Hef domain-like appears in SCOPe 2.01
  
• Family a.60.2.5: Hef domain-like appears in the current release, SCOPe 2.08