SCOPe 2.03: Domain d2v0mb1: 2v0m B:30-496

Lineage for d2v0mb1 (2v0m B:30-496)

1. Root: SCOPe 2.03

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.104: Cytochrome P450 [48263] (1 superfamily)
   multihelical

4. Superfamily a.104.1: Cytochrome P450 [48264] (2 families)

5. Family a.104.1.1: Cytochrome P450 [48265] (23 proteins)

6. Protein Mammalian cytochrome P450 3a4 [109958] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [109959] (6 PDB entries)
   Uniprot P08684

8. Domain d2v0mb1: 2v0m B:30-496 [140051]
   complexed with hem, kln

Details for d2v0mb1

PDB Entry: 2v0m, 2.8 Å

PDB Description: crystal structure of human p450 3a4 in complex with ketoconazole

PDB Compounds: (B:) cytochrome p450 3a4

SCOPe Domain Sequences for d2v0mb1:

Sequence, based on SEQRES records:

>d2v0mb1 a.104.1.1 (B:30-496) Mammalian cytochrome P450 3a4 {Human (Homo sapiens) [TaxId: 9606]}
hglfkklgipgptplpflgnilsyhkgfcmfdmechkkygkvwgfydgqqpvlaitdpdm
iktvlvkecysvftnrrpfgpvgfmksaisiaedeewkrlrsllsptftsgklkemvpii
aqygdvlvrnlrreaetgkpvtlkdvfgaysmdvitstsfgvnidslnnpqdpfventkk
llrfdfldpfflsitvfpflipilevlnicvfprevtnflrksvkrmkesrledtqkhrv
dflqlmidsqnsketeshkalsdlelvaqsiififagyettssvlsfimyelathpdvqq
klqeeidavlpnkapptydtvlqmeyldmvvnetlrlfpiamrlervckkdveingmfip
kgvvvmipsyalhrdpkywtepekflperfskknkdnidpyiytpfgsgprncigmrfal
mnmklalirvlqnfsfkpcketqiplklslggllqpekpvvlkvesr

Sequence, based on observed residues (ATOM records):

>d2v0mb1 a.104.1.1 (B:30-496) Mammalian cytochrome P450 3a4 {Human (Homo sapiens) [TaxId: 9606]}
hglfkklgipgptplpflgnilsyhkgfcmfdmechkkygkvwgfydgqqpvlaitdpdm
iktvlvkecysvftnrrpfgpvgfmksaisiaedeewkrlrsllsptftsgklkemvpii
aqygdvlvrnlrreaetgkpvtlkdvfgaysmdvitstsfgvnidslnnpqdpfventkk
llrfldpfflsitvfpflipilevlnicvfprevtnflrksvkrmkesrledvdflqlmi
dsqalsdlelvaqsiififagyettssvlsfimyelathpdvqqklqeeidavlpnkapp
tydtvlqmeyldmvvnetlrlfpiamrlervckkdveingmfipkgvvvmipsyalhrdp
kywtepekflperfskknkdnidpyiytpfgsgprncigmrfalmnmklalirvlqnfsf
kpcketqiplklslggllqpekpvvlkvesr

Timeline for d2v0mb1:

• d2v0mb1 first appeared in SCOP 1.73
  
• d2v0mb1 appears in SCOPe 2.02
  
• d2v0mb1 appears in SCOPe 2.04
  
• d2v0mb1 appears in the current release, SCOPe 2.08