SCOPe 2.05: Domain d2pvwa3: 2pvw A:57-117,A:351-593

Lineage for d2pvwa3 (2pvw A:57-117,A:351-593)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.56: Phosphorylase/hydrolase-like [53162] (8 superfamilies)
   core: 3 layers, a/b/a ; mixed sheet of 5 strands: order 21354; strand 4 is antiparallel to the rest; contains crossover loops

4. Superfamily c.56.5: Zn-dependent exopeptidases [53187] (10 families)
   core: mixed beta-sheet of 8 strands, order 12435867; strands 2, 6 & 7 are antiparallel to the rest

5. Family c.56.5.5: FolH catalytic domain-like [53210] (2 proteins)

6. Protein Glutamate carboxypeptidase II FOLH1 [142522] (1 species)
   Folate hydrolase 1, FolH homologue

7. Species Human (Homo sapiens) [TaxId:9606] [142523] (23 PDB entries)
   Uniprot Q04609 57-117,351-593

8. Domain d2pvwa3: 2pvw A:57-117,A:351-593 [139757]
   Other proteins in same PDB: d2pvwa1, d2pvwa2
   automatically matched to 2C6C A:57-117,A:351-593
   complexed with ca, cl, g88, nag, zn

Details for d2pvwa3

PDB Entry: 2pvw, 1.71 Å

PDB Description: a high resolution structure of human glutamate carboxypeptidase ii (gcpii) in complex with 2-(phosphonomethyl)pentanedioic acid (2-pmpa)

PDB Compounds: (A:) glutamate carboxypeptidase 2

SCOPe Domain Sequences for d2pvwa3:

Sequence, based on SEQRES records:

>d2pvwa3 c.56.5.5 (A:57-117,A:351-593) Glutamate carboxypeptidase II FOLH1 {Human (Homo sapiens) [TaxId: 9606]}
nmkafldelkaenikkflynftqiphlagteqnfqlakqiqsqwkefgldsvelahydvl
lXevtriynvigtlrgavepdryvilgghrdswvfggidpqsgaavvheivrsfgtlkke
gwrprrtilfaswdaeefgllgstewaeensrllqergvayinadssiegnytlrvdctp
lmyslvhnltkelkspdegfegkslyeswtkkspspefsgmprisklgsgndfevffqrl
giasgrarytknwetnkfsgyplyhsvyetyelvekfydpmfkyhltvaqvrggmvfela
nsivl

Sequence, based on observed residues (ATOM records):

>d2pvwa3 c.56.5.5 (A:57-117,A:351-593) Glutamate carboxypeptidase II FOLH1 {Human (Homo sapiens) [TaxId: 9606]}
nmkafldelkaenikkflynftqiphlagteqnfqlakqiqsqwkefgldsvelahydvl
lXevtriynvigtlrgavepdryvilgghrdswvfggidpqsgaavvheivrsfgtlkke
gwrprrtilfaswdaeefgllgstewaeensrllqergvayinadssiegnytlrvdctp
lmyslvhnltkelkspdegfegkslyeswtkkspspefsgmprisklgsgndfevffqrl
giasgrarytknnkfsgyplyhsvyetyelvekfydpmfkyhltvaqvrggmvfelansi
vl

Timeline for d2pvwa3:

• d2pvwa3 first appeared in SCOP 1.73
  
• d2pvwa3 appears in SCOPe 2.04
  
• d2pvwa3 appears in SCOPe 2.06
  
• d2pvwa3 appears in the current release, SCOPe 2.08