Lineage for d2pr4h2 (2pr4 H:133-232)

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2017115Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 2017116Superfamily b.1.1: Immunoglobulin [48726] (5 families) (S)
  5. 2020524Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 protein domains)
  6. 2022294Protein Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma [88574] (6 species)
  7. 2022298Species Human (Homo sapiens) [TaxId:9606] [88575] (179 PDB entries)
    including humanized antibodies (chimeric proteins with human constant domains)
    Uniprot Q6N089 20-243 # 95% sequence identity; natural chimera: antibody heavy chain (Fab HYB3) ! SQ NA # humanized antibody ! Uniprot P01857 # IGHG1_HUMAN Ig gamma-1 chain C region ! SQ NA # engineered antibody
  8. 2022354Domain d2pr4h2: 2pr4 H:133-232 [139749]
    Other proteins in same PDB: d2pr4h1, d2pr4l1, d2pr4l2
    automatically matched to d2f5ah2

Details for d2pr4h2

PDB Entry: 2pr4 (more details), 2.05 Å

PDB Description: Crystal Structure of Fab' from the HIV-1 Neutralizing Antibody 2F5
PDB Compounds: (H:) nmAb 2F5 Fab' light Chain

SCOPe Domain Sequences for d2pr4h2:

Sequence, based on SEQRES records: (download)

>d2pr4h2 b.1.1.2 (H:133-232) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma {Human (Homo sapiens) [TaxId: 9606]}
tstkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
glyslssvvtvpssslgtqtytcnvnhkpsntkvdkrvep

Sequence, based on observed residues (ATOM records): (download)

>d2pr4h2 b.1.1.2 (H:133-232) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma {Human (Homo sapiens) [TaxId: 9606]}
tstkgpsvfplapssggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglys
lssvvtvpssslgtqtytcnvnhkpsntkvdkrvep

SCOPe Domain Coordinates for d2pr4h2:

Click to download the PDB-style file with coordinates for d2pr4h2.
(The format of our PDB-style files is described here.)

Timeline for d2pr4h2:

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Domains from same chain:
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d2pr4h1