SCOPe 2.08: Domain d2pi4a_: 2pi4 A:

Lineage for d2pi4a_ (2pi4 A:)

1. Root: SCOPe 2.08

2. Class e: Multi-domain proteins (alpha and beta) [56572] (74 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (9 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.3: T7 RNA polymerase [56691] (2 proteins)

6. Protein T7 RNA polymerase [56692] (1 species)
   multidomain; mostly alpha

7. Species Bacteriophage T7 [TaxId:10760] [56693] (11 PDB entries)

8. Domain d2pi4a_: 2pi4 A: [139700]
   automated match to d1ceza_
   protein/DNA complex; protein/RNA complex; complexed with gh3, mg

Details for d2pi4a_

PDB Entry: 2pi4, 2.5 Å

PDB Description: T7RNAP complexed with a phi10 protein and initiating GTPs.

PDB Compounds: (A:) DNA-directed RNA polymerase

SCOPe Domain Sequences for d2pi4a_:

Sequence, based on SEQRES records:

>d2pi4a_ e.8.1.3 (A:) T7 RNA polymerase {Bacteriophage T7 [TaxId: 10760]}
iakndfsdielaaipfntladhygerlareqlalehesyemgearfrkmferqlkageva
dnaaakplittllpkmiarindwfeevkakrgkrptafqflqeikpeavayitikttlac
ltsadnttvqavasaigraiedearfgrirdleakhfkknveeqlnkrvghvykkafmqv
veadmlskgllggeawsswhkedsihvgvrciemliestgmvslhrqnagvvgqdsetie
lapeyaeaiatragalagispmfqpcvvppkpwtgitgggywangrrplalvrthskkal
mryedvympevykainiaqntawkinkkvlavanvitkwkhcpvedipaiereelpmkpe
didmnpealtawkraaaavyrkdkarksrrislefmleqankfanhkaiwfpynmdwrgr
vyavsmfnpqgndmtkglltlakgkpigkegyywlkihgancagvdkvpfperikfieen
henimacaksplentwwaeqdspfcflafcfeyagvqhhglsyncslplafdgscsgiqh
fsamlrdevggravnllpsetvqdiygivakkvneilqadaingtdnevvtvtdentgei
sekvklgtkalagqwlaygvtrsvtkrsvmtlaygskefgfrqqvledtiqpaidsgkgl
mftqpnqaagymakliwesvsvtvvaaveamnwlksaakllaaevkdkktgeilrkrcav
hwvtpdgfpvwqeykkpiqtrlnlmflgqfrlqptintnkdseidahkqesgiapnfvhs
qdgshlrktvvwahekygiesfalihdsfgtipadaanlfkavretmvdtyescdvladf
ydqfadqlhesqldkmpalpakgnlnlrdilesdfafa

Sequence, based on observed residues (ATOM records):

>d2pi4a_ e.8.1.3 (A:) T7 RNA polymerase {Bacteriophage T7 [TaxId: 10760]}
iakndfsdielaaipfntladhygerlareqlalehesyemgearfrkmfplittllpkm
iarindwfeevkakrgkrptafqflqeikpeavayitikttlacltsadnttvqavasai
graiedearfgrirdleakhfkknveeqlnkrvghvykkafmqvveadmlskgllggeaw
sswhkedsihvgvrciemliestgmvslhrqnagvvgqdsetielapeyaeaiatragal
agispmfqpcvvppkpwtgitgggywangrrplalvrthskkalmryedvympevykain
iaqntawkinkkvlavanvitkwkhcpvedipaiereelpmkpedidmnpealtawkraa
aavyrkdkarksrrislefmleqankfanhkaiwfpynmdwrgrvyavsmfnpqgndmtk
glltlakgkpigkegyywlkihgancagvdkvpfperikfieenhenimacaksplentw
waeqdspfcflafcfeyagvqhhglsyncslplafdgscsgiqhfsamlrdevggravnl
lpsetvqdiygivakkvneilqadaingtdnevvtvtdentgeisekvklgtkalagqwl
aygvtrsvtkrsvmtlaygskefgfrqqvledtiqpaidsgkglmftqpnqaagymakli
wesvsvtvvaaveamnwlksaakllaaevkdkktgeilrkrcavhwvtpdgfpvwqeykk
piqtrlnlmflgqfrlqptintnkdseidahkqesgiapnfvhsqdgshlrktvvwahek
ygiesfalihdsfgtipadaanlfkavretmvdtyescdvladfydqfadqlhesqldkm
palpakgnlnlrdilesdfafa

Timeline for d2pi4a_:

• d2pi4a_ first appeared in SCOP 1.73, called d2pi4a1
  
• d2pi4a_ appears in SCOPe 2.07