SCOPe 2.08: Domain d2pe2a_: 2pe2 A:

Lineage for d2pe2a_ (2pe2 A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein 3-phosphoinositide dependent protein kinase-1 Pdk1 [90036] (1 species)
   AGC group; PBK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [90037] (25 PDB entries)
   Uniprot O15530 75-363

8. Domain d2pe2a_: 2pe2 A: [139666]
   automated match to d1h1wa_
   complexed with 464, gol, so4

Details for d2pe2a_

PDB Entry: 2pe2, 2.13 Å

PDB Description: crystal structure of human phosphoinositide-dependent protein kinase 1 (pdk1) 3-{5-[2-oxo-5-ureido-1,2-dihydro-indol-(3z)-ylidenemethyl]-1h-pyrrol-3-yl}-n-(2-piperidin-1-yl-ethyl)-benzamide complex

PDB Compounds: (A:) 3-phosphoinositide-dependent protein kinase 1

SCOPe Domain Sequences for d2pe2a_:

Sequence, based on SEQRES records:

>d2pe2a_ d.144.1.7 (A:) 3-phosphoinositide dependent protein kinase-1 Pdk1 {Human (Homo sapiens) [TaxId: 9606]}
prkkrpedfkfgkilgegsfstvvlarelatsreyaikilekrhiikenkvpyvtrerdv
msrldhpffvklyftfqddeklyfglsyakngellkyirkigsfdetctrfytaeivsal
eylhgkgiihrdlkpenillnedmhiqitdfgtakvlspeskqaransfvgtaqyvspel
lteksackssdlwalgciiyqlvaglppfragneylifqkiikleydfpekffpkardlv
ekllvldatkrlgceemegygplkahpffesvtwenlhqqtppklt

Sequence, based on observed residues (ATOM records):

>d2pe2a_ d.144.1.7 (A:) 3-phosphoinositide dependent protein kinase-1 Pdk1 {Human (Homo sapiens) [TaxId: 9606]}
prkkrpedfkfgkilgegsfstvvlarelatsreyaikilekrhiikenkvpyvtrerdv
msrldhpffvklyftfqddeklyfglsyakngellkyirkigsfdetctrfytaeivsal
eylhgkgiihrdlkpenillnedmhiqitdfgtakvlsfvgtaqyvspellteksackss
dlwalgciiyqlvaglppfragneylifqkiikleydfpekffpkardlvekllvldatk
rlgceemegygplkahpffesvtwenlhqqtppklt

Timeline for d2pe2a_:

• d2pe2a_ first appeared in SCOP 1.73, called d2pe2a1
  
• d2pe2a_ appears in SCOPe 2.07