SCOP 1.75: Domain d2pe0a1: 2pe0 A:74-359

Lineage for d2pe0a1 (2pe0 A:74-359)

1. Root: SCOP 1.75

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (7 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (63 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein 3-phosphoinositide dependent protein kinase-1 Pdk1 [90036] (1 species)
   AGC group; PBK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [90037] (13 PDB entries)
   Uniprot O15530 75-363

8. Domain d2pe0a1: 2pe0 A:74-359 [139664]
   automatically matched to d1h1wa_
   complexed with 39z, gol, so4

Details for d2pe0a1

PDB Entry: 2pe0, 2.35 Å

PDB Description: crystal structure of human phosphoinositide-dependent protein kinase 1 (pdk1) 5-hydroxy-3-[1-(1h-pyrrol-2-yl)-eth-(z)-ylidene]-1,3-dihydro-indol-2-one complex

PDB Compounds: (A:) 3-phosphoinositide-dependent protein kinase 1

SCOP Domain Sequences for d2pe0a1:

Sequence, based on SEQRES records:

>d2pe0a1 d.144.1.7 (A:74-359) 3-phosphoinositide dependent protein kinase-1 Pdk1 {Human (Homo sapiens) [TaxId: 9606]}
prkkrpedfkfgkilgegsfstvvlarelatsreyaikilekrhiikenkvpyvtrerdv
msrldhpffvklyftfqddeklyfglsyakngellkyirkigsfdetctrfytaeivsal
eylhgkgiihrdlkpenillnedmhiqitdfgtakvlspeskqaransfvgtaqyvspel
lteksackssdlwalgciiyqlvaglppfragneylifqkiikleydfpekffpkardlv
ekllvldatkrlgceemegygplkahpffesvtwenlhqqtppklt

Sequence, based on observed residues (ATOM records):

>d2pe0a1 d.144.1.7 (A:74-359) 3-phosphoinositide dependent protein kinase-1 Pdk1 {Human (Homo sapiens) [TaxId: 9606]}
prkkrpedfkfgkilgegsfstvvlarelatsreyaikilekrhiikenkvpyvtrerdv
msrldhpffvklyftfqddeklyfglsyakngellkyirkigsfdetctrfytaeivsal
eylhgkgiihrdlkpenillnedmhiqitdfgtakvlsfvgtaqyvspellteksackss
dlwalgciiyqlvaglppfragneylifqkiikleydfpekffpkardlvekllvldatk
rlgceemegygplkahpffesvtwenlhqqtppklt

Timeline for d2pe0a1:

• d2pe0a1 first appeared in SCOP 1.73
  
• d2pe0a1 is called d2pe0a_ in SCOPe 2.01
  
• d2pe0a1 appears in the current release, SCOPe 2.08, called d2pe0a_