SCOP 1.73: Domain d2p2ib1: 2p2i B:820-1168

Lineage for d2p2ib1 (2p2i B:820-1168)

1. Root: SCOP 1.73

2. Class d: Alpha and beta proteins (a+b) [53931] (334 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (7 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (61 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Vascular endothelial growth factor receptor 2 (kdr) [56160] (1 species)
   PTK group; PDGFR/VEGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56161] (3 PDB entries)

8. Domain d2p2ib1: 2p2i B:820-1168 [139464]
   automatically matched to d1vr2a_
   complexed with 608; mutant

Details for d2p2ib1

PDB Entry: 2p2i, 2.4 Å

PDB Description: crystal structure of the vegfr2 kinase domain in complex with a nicotinamide inhibitor

PDB Compounds: (B:) Vascular endothelial growth factor receptor 2

SCOP Domain Sequences for d2p2ib1:

Sequence, based on SEQRES records:

>d2p2ib1 d.144.1.7 (B:820-1168) Vascular endothelial growth factor receptor 2 (kdr) {Human (Homo sapiens) [TaxId: 9606]}
lpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavkmlkegathseh
ralmselkilihighhlnvvnllgactkpggplmvivefckfgnlstylrskrnefvpyk
vapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvkicdfgl
ardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgaspypgv
kideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnllqana

Sequence, based on observed residues (ATOM records):

>d2p2ib1 d.144.1.7 (B:820-1168) Vascular endothelial growth factor receptor 2 (kdr) {Human (Homo sapiens) [TaxId: 9606]}
lpydaskwefprdrlklgkplgrgqvieadafgidktatcrtvavkmlthsehralmsel
kilihighhlnvvnllgactkpggplmvivefckfgnlstylrskrnefvpykfltlehl
icysfqvakgmeflasrkcihrdlaarnillseknvvkicdfplkwmapetifdrvytiq
sdvwsfgvllweifslgaspypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhg
epsqrptfselvehlgnllqana

Timeline for d2p2ib1:

• d2p2ib1 is new in SCOP 1.73
  
• d2p2ib1 appears in SCOP 1.75
  
• d2p2ib1 appears in the current release, SCOPe 2.08, called d2p2ib_