Lineage for d2ozld1 (2ozl D:0-191)

  1. Root: SCOP 1.75
  2. 814173Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 828800Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. 828801Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (8 families) (S)
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
  5. 828995Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module [88741] (4 proteins)
    parent family to TK and PFOR
    heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module
  6. 829035Protein E1-beta subunit of pyruvate dehydrogenase, Pyr module [69472] (2 species)
  7. 829038Species Human (Homo sapiens) [TaxId:9606] [89653] (2 PDB entries)
  8. 829040Domain d2ozld1: 2ozl D:0-191 [139449]
    Other proteins in same PDB: d2ozla1, d2ozlb2, d2ozlc1, d2ozld2
    automatically matched to d1ni4b1
    complexed with k, mg, tpp; mutant

Details for d2ozld1

PDB Entry: 2ozl (more details), 1.9 Å

PDB Description: Human pyruvate dehydrogenase S264E variant
PDB Compounds: (D:) Pyruvate dehydrogenase E1 component subunit beta

SCOP Domain Sequences for d2ozld1:

Sequence; same for both SEQRES and ATOM records: (download)

>d2ozld1 c.36.1.7 (D:0-191) E1-beta subunit of pyruvate dehydrogenase, Pyr module {Human (Homo sapiens) [TaxId: 9606]}
slqvtvrdainqgmdeelerdekvfllgeevaqydgaykvsrglwkkygdkriidtpise
mgfagiavgaamaglrpicefmtfnfsmqaidqvinsaaktyymsgglqpvpivfrgpng
asagvaaqhsqcfaawyghcpglkvvspwnsedakgliksairdnnpvvvlenelmygvp
fefppeaqskdf

SCOP Domain Coordinates for d2ozld1:

Click to download the PDB-style file with coordinates for d2ozld1.
(The format of our PDB-style files is described here.)

Timeline for d2ozld1: