SCOP 1.73: Domain d2orvb1: 2orv B:18-150

Lineage for d2orvb1 (2orv B:18-150)

1. Root: SCOP 1.73

2. Class c: Alpha and beta proteins (a/b) [51349] (141 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (24 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.24: Type II thymidine kinase [117558] (1 protein)
   N-terminal part of Pfam PF00265; parallel beta-sheet of 6 strands, order 324516; topological similarity to the RecA-like proteins, especially CobA (scop_pr 52684)

6. Protein Thymidine kinase, TK1, N-terminal domain [117559] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [117560] (2 PDB entries)

8. Domain d2orvb1: 2orv B:18-150 [139276]
   Other proteins in same PDB: d2orva2, d2orvb2
   automatically matched to d1xbta1
   complexed with 4ta, zn; mutant

Details for d2orvb1

PDB Entry: 2orv, 2.3 Å

PDB Description: human thymidine kinase 1 in complex with tp4a

PDB Compounds: (B:) Thymidine kinase

SCOP Domain Sequences for d2orvb1:

Sequence, based on SEQRES records:

>d2orvb1 c.37.1.24 (B:18-150) Thymidine kinase, TK1, N-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
rgqiqvilgpmfsgkstelmrrvrrfqiaqykclvikyakdtrysssfcthdrntmealp
acllrdvaqealgvavigidegqffpdivefceamanagktvivaaldgtfqrkpfgail
nlvplaesvvklt

Sequence, based on observed residues (ATOM records):

>d2orvb1 c.37.1.24 (B:18-150) Thymidine kinase, TK1, N-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
rgqiqvilgpmfsgkstelmrrvrrfqiaqykclvikyakdmealpacllrdvaqealgv
avigidegqffpdivefceamanagktvivaaldgtfqrkpfgailnlvplaesvvklt

Timeline for d2orvb1:

• d2orvb1 is new in SCOP 1.73
  
• d2orvb1 appears in SCOP 1.75
  
• d2orvb1 appears in the current release, SCOPe 2.08